Virus-specific CD4+ and CD8+ Cytotoxic T-cell Responses and Long-term T-cell Memory in Individuals Vaccinated Against Polio

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2005 Apr 29

PMID 15857985

Citations 35

Authors

Rahnuma Wahid

Martin J Cannon

Marie Chow

Affiliations

Soon will be listed here.

Abstract

The presence of poliovirus (PV)-specific CD4(+) T cells in individuals vaccinated against polio has been shown, but CD8(+) T-cell responses have not been described. Here, we functionally characterize the CD4(+) T-cell response and show for the first time that dendritic cells and macrophages can stimulate PV-specific CD8(+) T-cell responses in vitro from vaccinees. Both CD4(+) T and CD8(+) T cells secrete gamma interferon in response to PV antigens and are cytotoxic via the perforin/granzyme B-mediated pathway. Furthermore, the T cells also recognize and kill Sabin 1 vaccine-infected targets. The macrophage-stimulated CD4(+) T and CD8(+) T cells most likely represent memory T cells that persist for long periods in vaccinated individuals. Thus, immunity to PV vaccination involves not only an effective neutralizing antibody titer but also long-term CD4(+) and CD8(+) cytotoxic T-cell responses.

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