T Cell Responses to Vaccines in Infants: Defective IFNgamma Production After Oral Polio Vaccination

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2002 Apr 23

PMID 11966766

Citations 32

Authors

J Vekemans

M O C Ota

E C Y Wang

M Kidd

L K Borysiewicz

H Whittle

K P W J McAdam

G MORGAN

A Marchant

Affiliations

Soon will be listed here.

Abstract

The immaturity of the neonatal immune system is associated with an increased susceptibility to infections. Studies in mice indicate that neonatal immune responses are biased towards the T helper 2 type, but little is known about helper T cell responses in human newborns. In this study, the oral polio vaccine was used as a model of early immunization to investigate the capacity of young infants to develop cellular immune responses. We show that neonatal immunization with oral polio vaccine induces the production of high titres of neutralizing antibodies but reduced proliferative and IFNgamma responses to polio antigens compared to immune adults. These data suggest that specific strategies will be required to immunize newborns against pathogens controlled by Th1 type immune responses.

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References

Adkins B, Bu Y, Guevara P . The generation of Th memory in neonates versus adults: prolonged primary Th2 effector function and impaired development of Th1 memory effector function in murine neonates. J Immunol. 2001; 166(2):918-25. DOI: 10.4049/jimmunol.166.2.918. View

Aberle J, Aberle S, Dworzak M, Mandl C, Rebhandl W, Vollnhofer G . Reduced interferon-gamma expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease. Am J Respir Crit Care Med. 1999; 160(4):1263-8. DOI: 10.1164/ajrccm.160.4.9812025. View

Siegrist C . Neonatal and early life vaccinology. Vaccine. 2001; 19(25-26):3331-46. DOI: 10.1016/s0264-410x(01)00028-7. View

Vekemans J, Amedei A, Ota M, DElios M, Goetghebuer T, Ismaili J . Neonatal bacillus Calmette-Guérin vaccination induces adult-like IFN-gamma production by CD4+ T lymphocytes. Eur J Immunol. 2001; 31(5):1531-5. DOI: 10.1002/1521-4141(200105)31:5<1531::AID-IMMU1531>3.0.CO;2-1. View

Burchett S, Corey L, Mohan K, Westall J, Ashley R, Wilson C . Diminished interferon-gamma and lymphocyte proliferation in neonatal and postpartum primary herpes simplex virus infection. J Infect Dis. 1992; 165(5):813-8. DOI: 10.1093/infdis/165.5.813. View

Graham S, Wang E, Jenkins O, Borysiewicz L . Analysis of the human T-cell response to picornaviruses: identification of T-cell epitopes close to B-cell epitopes in poliovirus. J Virol. 1993; 67(3):1627-37. PMC: 237534. DOI: 10.1128/JVI.67.3.1627-1637.1993. View

Inaba K, Inaba M, Naito M, Steinman R . Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med. 1993; 178(2):479-88. PMC: 2191128. DOI: 10.1084/jem.178.2.479. View

Mahon B, Katrak K, Nomoto A, Macadam A, Minor P, Mills K . Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. J Exp Med. 1995; 181(4):1285-92. PMC: 2191967. DOI: 10.1084/jem.181.4.1285. View

Forsthuber T, Yip H, Lehmann P . Induction of TH1 and TH2 immunity in neonatal mice. Science. 1996; 271(5256):1728-30. DOI: 10.1126/science.271.5256.1728. View

10.

Barrios C, Brawand P, Berney M, Brandt C, Lambert P, Siegrist C . Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2-biased pattern which persists after adult boosting. Eur J Immunol. 1996; 26(7):1489-96. DOI: 10.1002/eji.1830260713. View

11.

Mahon B, Ryan M, Griffin F, Mills K . Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells. Infect Immun. 1996; 64(12):5295-301. PMC: 174522. DOI: 10.1128/iai.64.12.5295-5301.1996. View

12.

Ryan M, Murphy G, Gothefors L, Nilsson L, Storsaeter J, Mills K . Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 T helper cells. J Infect Dis. 1997; 175(5):1246-50. DOI: 10.1086/593682. View

13.

Ausiello C, Urbani F, la Sala A, Lande R, Cassone A . Vaccine- and antigen-dependent type 1 and type 2 cytokine induction after primary vaccination of infants with whole-cell or acellular pertussis vaccines. Infect Immun. 1997; 65(6):2168-74. PMC: 175299. DOI: 10.1128/iai.65.6.2168-2174.1997. View

14.

Douek D, McFarland R, KEISER P, Gage E, Massey J, Haynes B . Changes in thymic function with age and during the treatment of HIV infection. Nature. 1999; 396(6712):690-5. DOI: 10.1038/25374. View

15.

Adkins B . T-cell function in newborn mice and humans. Immunol Today. 1999; 20(7):330-5. DOI: 10.1016/s0167-5699(99)01473-5. View

16.

Marchant A, Goetghebuer T, Ota M, Wolfe I, Ceesay S, De Groote D . Newborns develop a Th1-type immune response to Mycobacterium bovis bacillus Calmette-Guérin vaccination. J Immunol. 1999; 163(4):2249-55. View

17.

Goriely S, Vincart B, Stordeur P, Vekemans J, Willems F, Goldman M . Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes. J Immunol. 2001; 166(3):2141-6. DOI: 10.4049/jimmunol.166.3.2141. View