Neural Crest Stem Cell Maintenance by Combinatorial Wnt and BMP Signaling

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2005 Apr 20

PMID 15837799

Citations 75

Authors

Maurice Kleber

Hye-Youn Lee

Heiko Wurdak

Johanna Buchstaller

Martin M Riccomagno

Lars M Ittner

Ueli Suter

Douglas J Epstein

Lukas Sommer

Affiliations

Soon will be listed here.

Abstract

Canonical Wnt signaling instructively promotes sensory neurogenesis in early neural crest stem cells (eNCSCs) (Lee, H.Y., M. Kleber, L. Hari, V. Brault, U. Suter, M.M. Taketo, R. Kemler, and L. Sommer. 2004. Science. 303:1020-1023). However, during normal development Wnt signaling induces a sensory fate only in a subpopulation of eNCSCs while other cells maintain their stem cell features, despite the presence of Wnt activity. Hence, factors counteracting Wnt signaling must exist. Here, we show that bone morphogenic protein (BMP) signaling antagonizes the sensory fate-inducing activity of Wnt/beta-catenin. Intriguingly, Wnt and BMP act synergistically to suppress differentiation and to maintain NCSC marker expression and multipotency. Similar to NCSCs in vivo, NCSCs maintained in culture alter their responsiveness to instructive growth factors with time. Thus, stem cell development is regulated by combinatorial growth factor activities that interact with changing cell-intrinsic cues.

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