A Multivariate Test for Similarity of Two Dissolution Profiles

Overview

Journal J Biopharm Stat

Specialties Pharmacology
Public Health

Date 2005 Mar 31

PMID 15796294

Citations 5

Authors

H Saranadasa

K Krishnamoorthy

Affiliations

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Abstract

A multivariate test of size a for assessing the similarity of two dissolution profiles is proposed. The inferential procedure is developed by using the approach for the common mean problem in a multivariate setup due to Halperin (1961). The performance of the proposed method is compared with Intersection Union Test as well as f2 criterion recommended by the FDA through a simulation study. All the methods are illustrated with real examples.

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