Isocitrate Lyase (AceA) is Required for Salmonella Persistence but Not for Acute Lethal Infection in Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2005 Mar 24

PMID 15784602

Citations 56

Authors

Ferric C Fang

Stephen J Libby

Margaret E Castor

Angela M Fung

Affiliations

Soon will be listed here.

Abstract

Isocitrate lyase is required for fatty acid utilization via the glyoxylate shunt. Although isocitrate lyase is essential for Salmonella persistence during chronic infection, it is dispensable for acute lethal infection in mice. Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection.

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