Pilomyxoid Astrocytoma: a Review

Overview

Journal MedGenMed

Specialty General Medicine

Date 2005 Mar 19

PMID 15775869

Citations 23

Authors

Ricardo J Komotar

J Mocco

Benjamin S Carson

Michael E Sughrue

Brad E Zacharia

Alexander C Sisti

Peter D Canoll

Alexander G Khandji

Tarik Tihan

Peter C Burger

Jeffery N Bruce

Affiliations

Soon will be listed here.

Abstract

Pilomyxoid astrocytoma (PMA) is a recently described type of brain tumor. PMA shares similar features with pilocytic astrocytoma (PA), the most common central nervous system (CNS) tumor in the pediatric population, yet displays subtle histologic differences. Previous studies have shown PMA to behave more aggressively than PA, with shorter progression-free and overall survival as well as a higher rate of recurrence and CNS dissemination. These findings suggest that PMA may be a unique and distinct neoplasm. This review summarizes the histologic, clinical, and radiographic characteristics of PMA. In addition, the current treatment options and research endeavors involving this disease are described. Increased recognition of PMA within the medical community has the potential to affect the treatment and prognosis of pediatric low-grade astrocytomas.

Citing Articles

Pilomyxoid Astrocytoma Presenting With Developmental Regression: A Case Report.

Avuthu O, Salunkhe S, Patil M, Buch A, Mane S, Chugh A Cureus. 2024; 16(8):e67167.

PMID: 39295729 PMC: 11408975. DOI: 10.7759/cureus.67167.

Suprasellar pilocytic astrocytoma with leptomeningeal dissemination.

Zaini S, Hashim H, Rosani E, Bakar N, Yusoff S SA J Radiol. 2024; 28(1):2876.

PMID: 38840827 PMC: 11151406. DOI: 10.4102/sajr.v28i1.2876.

Pilocytic astrocytoma: The paradigmatic entity in low‑grade gliomas (Review).

Pizzimenti C, Fiorentino V, Germano A, Martini M, Ieni A, Tuccari G Oncol Lett. 2024; 27(4):146.

PMID: 38385109 PMC: 10879958. DOI: 10.3892/ol.2024.14279.

Benign Glioma.

Wu P, Filley A, Miller M, Bruce J Adv Exp Med Biol. 2023; 1405:31-71.

PMID: 37452934 DOI: 10.1007/978-3-031-23705-8_2.

A molecular study of pediatric pilomyxoid and pilocytic astrocytomas: Genome-wide copy number screening, retrospective analysis of clinicopathological features and long-term clinical outcome.

AlShail E, Alahmari A, Dababo A, Alsagob M, Al-Hindi H, Khalil H Front Oncol. 2023; 13:1034292.

PMID: 36860324 PMC: 9968872. DOI: 10.3389/fonc.2023.1034292.

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