Novel Dephosphotetrahydromethanopterin Biosynthesis Genes Discovered Via Mutagenesis in Methylobacterium Extorquens AM1

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2005 Mar 19

PMID 15774894

Citations 9

Authors

Ludmila Chistoserdova

Madeline E Rasche

Mary E Lidstrom

Affiliations

Soon will be listed here.

Abstract

Methylobacterium extorquens AM1 was used to explore the genetics of dephosphotetrahydromethanopterin (dH(4)MPT) biosynthesis. Strains with mutations in eight "archaeal-type" genes linked on the chromosome of M. extorquens AM1 were analyzed for the ability to synthesize dH(4)MPT, and six were found to be dH(4)MPT negative. Putative functions of these genes in dH(4)MPT biosynthesis are discussed.

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