Factors for Early Tumor Recurrence of Single Small Hepatocellular Carcinoma After Percutaneous Radiofrequency Ablation Therapy

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2005 Mar 17

PMID 15770718

Citations 21

Authors

Hsien-Chung Yu

Jin-Shiung Cheng

Kwok-Hung Lai

Chi-Pin Lin

Gin-Ho Lo

Chiun-Ku Lin

Ping-I Hsu

Hoi-Hung Chan

Ching-Chu Lo

Wei-Lun Tsai

Wen-Chi Chen

Affiliations

Soon will be listed here.

Abstract

Aim: To evaluate the factors affecting the early tumor recurrence within one year in cirrhotic patients having a single small hepatocellular carcinoma (HCC) after complete tumor necrosis by radiofrequency ablation (RFA) therapy.

Methods: Thirty patients with a single small HCC received RFA therapy by a RFA 2000 generator with LeVeen needle. Tri-phase computerized tomogram was followed every 2 to 3 mo after RFA. The clinical effects and tumor recurrence were recorded.

Results: The initial complete tumor necrosis rate was 86.7%. Twenty-two patients were followed for more than one year. The local and overall recurrence rates were 13.6% and 36.4%, 33.3% and 56.2%, 46.6% and 56.2% at 12, 24 and 30 mo, respectively. No major complication or procedure-related mortality was found. The risk factors for early local tumor recurrence within one year were larger tumor size, poor pathologic differentiation of tumor cells and advanced tumor staging. The age of patients with new tumor formation within one year was relatively younger (55.1+/-8.3 vs 66.7+/-10.8, P = 0.029).

Conclusion: Large tumor size, poor pathologic differentiation of tumor cells and advanced tumor staging are the risk factors for early local tumor recurrence within one year, and young age is the positive predictor for new tumor formation within one year.

Citing Articles

Combined Ultrasound and Computed Tomography Guidance in Radiofrequency Ablation for Hepatocellular Carcinoma Reduces Local Recurrence Rate.

Nagasawa S, Kuwano A, Tanaka K, Yada M, Masumoto A, Motomura K Cancer Diagn Progn. 2023; 3(6):660-666.

PMID: 37927810 PMC: 10619567. DOI: 10.21873/cdp.10269.

Predicting Outcome after Percutaneous Ablation for Early-Stage Hepatocellular Carcinoma Using Various Imaging Modalities.

Shimizu R, Ida Y, Kitano M Diagnostics (Basel). 2023; 13(19).

PMID: 37835800 PMC: 10572637. DOI: 10.3390/diagnostics13193058.

Detection of Incomplete Irreversible Electroporation (IRE) and Microwave Ablation (MWA) of Hepatocellular Carcinoma (HCC) Using Iodine Quantification in Dual Energy Computed Tomography (DECT).

Baumler W, Philipp Beyer L, Lurken L, Wiggermann P, Stroszczynski C, Dollinger M Diagnostics (Basel). 2022; 12(4).

PMID: 35454034 PMC: 9026630. DOI: 10.3390/diagnostics12040986.

Comparison of the safety and efficacy of hepatic resection and radiofrequency ablation in the treatment of single small hepatocellular carcinoma: systematic review and meta-analysis.

Wang K, Wang R, Liu S, Peng G, Yu H, Wang X Transl Cancer Res. 2022; 11(3):580-590.

PMID: 35402177 PMC: 8990824. DOI: 10.21037/tcr-22-563.

Exosome-transferred long non-coding RNA ASMTL-AS1 contributes to malignant phenotypes in residual hepatocellular carcinoma after insufficient radiofrequency ablation.

Ma D, Gao X, Liu Z, Lu X, Ju H, Zhang N Cell Prolif. 2020; 53(9):e12795.

PMID: 32722884 PMC: 7507479. DOI: 10.1111/cpr.12795.

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