Complex Memory T-cell Phenotypes Revealed by Coexpression of CD62L and CCR7

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2005 Mar 16

PMID 15767451

Citations 59

Authors

Heike Unsoeld

Hanspeter Pircher

Affiliations

Soon will be listed here.

Abstract

Antigen-experienced T cells have been divided into CD62L+ CCR7+ central memory (TCM) and CD62L- CCR7- effector memory (TEM) cells. Here, we examined coexpression of CD62L and CCR7 in lymphocytic choriomeningitis virus-specific memory CD8 T cells from both lymphoid and nonlymphoid tissues. Three main points emerged: firstly, memory cells frequently expressed a mixed CD62L- CCR7+ phenotype that differed from the phenotypes of classical TEM and TCM cells; secondly, TCM cells were not restricted to lymphoid organs but were also present in significant numbers in nonlymphoid tissues; and thirdly, a major shift from a TCM to TEM phenotype was found in memory cells that had been stimulated repetitively with antigen.

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