The Complex Role of Adipokines in Obesity, Inflammation, and Autoimmunity

Overview

Journal Clin Sci (Lond)

Specialties Biochemistry
General Medicine
Science

Date 2021 Mar 17

PMID 33729498

Citations 95

Authors

Erin B Taylor

Affiliations

Soon will be listed here.

Abstract

The global obesity epidemic is a major contributor to chronic disease and disability in the world today. Since the discovery of leptin in 1994, a multitude of studies have characterized the pathological changes that occur within adipose tissue in the obese state. One significant change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge on adipokine structure and physiological function, and focus on the known roles of these factors in the modulation of the immune response. I will also discuss adipokines in rheumatic and autoimmune diseases.

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