Anti-SSA/Ro Antibodies and the Heart: More Than Complete Congenital Heart Block? A Review of Electrocardiographic and Myocardial Abnormalities and of Treatment Options

Overview

Journal Arthritis Res Ther

Publisher Biomed Central

Specialty Rheumatology

Date 2005 Mar 4

PMID 15743492

Citations 20

Authors

Nathalie Costedoat-Chalumeau

Zahir Amoura

Elisabeth Villain

Laurence Cohen

Jean-Charles Piette

Affiliations

Soon will be listed here.

Abstract

Apart from complete and incomplete congenital heart block (CHB), new cardiac manifestations related to anti-SSA/Ro antibodies have been reported in children born to mothers bearing these antibodies. These manifestations include transient fetal first-degree heart block, prolongation of corrected QT (QTc) interval, sinus bradycardia, late-onset cardiomyopathy, endocardial fibroelastosis and cardiac malformations. Anti-SSA/Ro antibodies are not considered pathogenic to the adult heart, but a prolongation of the QTc interval has recently been reported in adult patients and is still a matter of debate. Treatment of CHB is not well established and needs to be assessed carefully. The risks and benefits of prenatal fluorinated steroids are discussed.

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