Single Turn Peptide Alpha Helices with Exceptional Stability in Water

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2005 Mar 3

PMID 15740134

Citations 80

Authors

Nicholas E Shepherd

Huy N Hoang

Giovanni Abbenante

David P Fairlie

Affiliations

Soon will be listed here.

Abstract

Cyclic pentapeptides are not known to exist in alpha-helical conformations. CD and NMR spectra show that specific 20-membered cyclic pentapeptides, Ac-(cyclo-1,5) [KxxxD]-NH(2) and Ac-(cyclo-2,6)-R[KxxxD]-NH(2), are highly alpha-helical structures in water and independent of concentration, TFE, denaturants, and proteases. These are the smallest alpha-helical peptides in water.

Citing Articles

Late-Stage Minimal Labeling of Peptides and Proteins for Real-Time Imaging of Cellular Trafficking.

Nadal-Bufi F, Nithun R, de Moliner F, Lin X, Habiballah S, Jbara M ACS Cent Sci. 2025; 11(1):66-75.

PMID: 39866693 PMC: 11758221. DOI: 10.1021/acscentsci.4c01249.

Stoichiometry-controlled secondary structure transition of amyloid-derived supramolecular dipeptide co-assemblies.

Ji W, Yuan C, Chakraborty P, Gilead S, Yan X, Gazit E Commun Chem. 2024; 2(1).

PMID: 39651426 PMC: 7617032. DOI: 10.1038/s42004-019-0170-z.

Enhanced circularly polarized luminescence attained self-assembly of heterochiral as opposed to homochiral dipeptides in water.

Bera S, Umesh , Bhattacharya S Chem Sci. 2024; .

PMID: 39144467 PMC: 11320125. DOI: 10.1039/d4sc01631a.

Enhancing the Intrinsic Antiplasmodial Activity and Improving the Stability and Selectivity of a Tunable Peptide Scaffold Derived from Human Platelet Factor 4.

Lawrence N, Handley T, de Veer S, Harding M, Andraszek A, Hall L ACS Infect Dis. 2024; 10(8):2899-2912.

PMID: 39087267 PMC: 11320574. DOI: 10.1021/acsinfecdis.4c00276.

Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers.

DiGiorno M, Vithanage N, Victorio C, Kreitler D, Outlaw V, Sawyer N Res Sq. 2024; .

PMID: 39070635 PMC: 11275974. DOI: 10.21203/rs.3.rs-4644285/v1.