Disequilibrium in Distribution of Resistance Mutations Among Mycobacterium Tuberculosis Beijing and Non-Beijing Strains Isolated from Patients in Germany

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2005 Feb 25

PMID 15728936

Citations 28

Authors

Doris Hillemann

Tanja Kubica

Sabine Rusch-Gerdes

Stefan Niemann

Affiliations

Soon will be listed here.

Abstract

Genotypic analysis of 103 multidrug-resistant Mycobacterium tuberculosis strains isolated in Germany in 2001 revealed that mutations in codon 531 (75.7%) of the rpoB gene and codon 315 (88.4%) of the katG gene are most frequent. Beijing genotype strains (60.2% of all isolates) displayed a different distribution of resistance mutations than non-Beijing strains.

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