Pim Kinases Are Upregulated During Epstein-Barr Virus Infection and Enhance EBNA2 Activity

Overview

Journal Virology

Specialty Microbiology

Date 2005 Feb 22

PMID 15721354

Citations 16

Authors

Eeva-Marja Rainio

Helena Ahlfors

Kara L Carter

Marja Ruuska

Sampsa Matikainen

Elliott Kieff

Paivi J Koskinen

Affiliations

Soon will be listed here.

Abstract

Latent Epstein-Barr virus (EBV) infection is strongly associated with B-cell proliferative diseases such as Burkitt's lymphoma. Here we show that the oncogenic serine/threonine kinases Pim-1 and Pim-2 enhance the activity of the viral transcriptional activator EBNA2. During EBV infection of primary B-lymphocytes, the mRNA expression levels of pim genes, especially of pim-2, are upregulated and remain elevated in latently infected B-cell lines. Thus, EBV-induced upregulation of Pim kinases and Pim-stimulated EBNA2 transcriptional activity may contribute to the ability of EBV to immortalize B-cells and predispose them to malignant growth.

Citing Articles

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Lai L, Chen X, Tian G, Liang R, Chen X, Qin Y Cancer Control. 2022; 29:10732748221106268.

PMID: 35844176 PMC: 9290152. DOI: 10.1177/10732748221106268.

Targeting Host PIM Protein Kinases Reduces Mayaro Virus Replication.

Sugasti-Salazar M, Campos D, Valdes-Torres P, Galan-Jurado P, Gonzalez-Santamaria J Viruses. 2022; 14(2).

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Feedback Loop Regulation between Pim Kinases and Tax Keeps Human T-Cell Leukemia Virus Type 1 Viral Replication in Check.

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PMID: 34818069 PMC: 8826812. DOI: 10.1128/JVI.01960-21.

The emerging regulatory roles of noncoding RNAs in immune function of fish: MicroRNAs versus long noncoding RNAs.

Abo-Al-Ela H Mol Genet Genomics. 2021; 296(4):765-781.

PMID: 33904988 DOI: 10.1007/s00438-021-01786-x.

PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells.

Cervantes-Gomez F, Stellrecht C, Ayres M, Keating M, Wierda W, Gandhi V Oncotarget. 2019; 10(29):2793-2809.

PMID: 31073371 PMC: 6497463. DOI: 10.18632/oncotarget.26876.