Sampsa Matikainen
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Explore the profile of Sampsa Matikainen including associated specialties, affiliations and a list of published articles.
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90
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4194
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Recent Articles
1.
Nurmi K, Silventoinen K, Keskitalo S, Rajamaki K, Kouri V, Kinnunen M, et al.
Cell Rep Med
. 2024 Apr;
5(4):101503.
PMID: 38593810
In monogenic autoinflammatory diseases, mutations in genes regulating innate immune responses often lead to uncontrolled activation of inflammasome pathways or the type I interferon (IFN-I) response. We describe a mechanism...
2.
Lorey M, Youssef A, Aikas L, Borrelli M, Hermansson M, Assini J, et al.
Front Cardiovasc Med
. 2023 Jun;
10:1130162.
PMID: 37293282
Introduction: Lipoprotein(a) (Lp(a)) is an LDL-like particle with an additional apolipoprotein (apo)(a) covalently attached. Elevated levels of circulating Lp(a) are a risk factor for atherosclerosis. A proinflammatory role for Lp(a)...
3.
Cypryk W, Czernek L, Horodecka K, Chrzanowski J, Stanczak M, Nurmi K, et al.
J Immunol
. 2022 Dec;
210(3):322-334.
PMID: 36525001
Human macrophages secrete extracellular vesicles (EVs) loaded with numerous immunoregulatory proteins. Vesicle-mediated protein secretion in macrophages is regulated by poorly characterized mechanisms; however, it is now known that inflammatory conditions...
4.
Kaivola J, Nyman T, Matikainen S
Viruses
. 2021 Dec;
13(12).
PMID: 34960782
SARS-CoV-2 is a new type of coronavirus that has caused worldwide pandemic. The disease induced by SARS-CoV-2 is called COVID-19. A majority of people with COVID-19 have relatively mild respiratory...
5.
Nurmi K, Niemi K, Kareinen I, Silventoinen K, Lorey M, Chen Y, et al.
Clin Transl Immunology
. 2021 Aug;
10(8):e1323.
PMID: 34377468
Objectives: The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by...
6.
Matikainen S, Nyman T, Cypryk W
J Cell Biol
. 2020 Sep;
219(10).
PMID: 32970793
Inflammasomes are multiprotein complexes of the innate immune system. Their activation leads to robust secretion of exosomes. In this issue, Wozniak et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201912074) reveal a...
7.
Matikainen S, Nyman T, Cypryk W
J Immunol
. 2020 Jun;
204(12):3063-3069.
PMID: 32513874
Inflammasomes are multiprotein complexes of the innate immune system that orchestrate development of inflammation by activating the secretion of proinflammatory cytokines, IL-1β and IL-18. The LPS of Gram-negative bacteria have...
8.
Cypryk W, Nyman T, Matikainen S
Front Immunol
. 2018 Oct;
9:2188.
PMID: 30319640
Inflammasomes are intracellular protein complexes of pattern recognition receptors and caspase-1, with essential functions in regulating inflammatory responses of macrophages and dendritic cells. The primary role of inflammasomes is to...
9.
Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, et al.
Viruses
. 2017 Sep;
9(10).
PMID: 28946654
Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here...
10.
Aittomaki S, Valanne S, Lehtinen T, Matikainen S, Nyman T, Ramet M, et al.
FASEB J
. 2017 Jul;
31(11):4770-4782.
PMID: 28705811
Invading pathogens provoke robust innate immune responses in Dipteran insects, such as In a systemic bacterial infection, a humoral response is induced in the fat body. Gram-positive bacteria trigger the...