Fast and Systematic Genome-wide Discovery of Conserved Regulatory Elements Using a Non-alignment Based Approach

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2005 Feb 8

PMID 15693947

Citations 78

Authors

Olivier Elemento

Saeed Tavazoie

Affiliations

Soon will be listed here.

Abstract

We describe a powerful new approach for discovering globally conserved regulatory elements between two genomes. The method is fast, simple and comprehensive, without requiring alignments. Its application to pairs of yeasts, worms, flies and mammals yields a large number of known and novel putative regulatory elements. Many of these are validated by independent biological observations, have spatial and/or orientation biases, are co-conserved with other elements and show surprising conservation across large phylogenetic distances.

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