New Triple-helix DNA Stabilizing Agents

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2005 Feb 3

PMID 15686920

Citations 5

Authors

Lucjan Strekowski

Maryam Hojjat

Ewa Wolinska

Alesia N Parker

Ekaterina Paliakov

Tadeusz Gorecki

Farial A Tanious

W David Wilson

Affiliations

Soon will be listed here.

Abstract

Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA.2polydT and duplex polydA.polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T.A.T triplets and triple/duplex selectivity were designed through a rational approach.

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