Predictive and Reactive Finger Force Control During Catching in Cerebellar Degeneration

Overview

Journal Cerebellum

Publisher Springer

Specialty Neurology

Date 2005 Feb 3

PMID 15686101

Citations 27

Authors

Dennis A Nowak

Joachim Hermsdorfer

Katrin Rost

Dagmar Timmann

Helge Topka

Affiliations

Soon will be listed here.

Abstract

We investigated how patients with cerebellar degeneration control fingertip forces to resist a perturbation imposed on a handheld load. Patients and healthy sex- and age-matched control subjects held an instrumented receptacle between the index finger and thumb. A weight was dropped into the receptacle either unexpectedly from the experimenter's hand with the subject being blindfolded or expectedly from the subject's opposite hand. This paradigm allowed us to study predictive and reactive modes of finger force control. Patients generated an overshoot of grip force, irrespective of whether the weight was dropped expectedly or unexpectedly. When the weight was dropped from the experimenter's hand, grip force lagged behind the load perturbation at impact in patients and controls. When the weight was dropped expectedly from the subject's opposite hand, healthy subjects started to increase grip force prior to the release of the weight. This observation is indicative for a predictive mode of force control. In contrast, the grip force profile of cerebellar patients was not processed in anticipation of the time of impact when the weight was dropped from the opposite hand. Our data suggest involvement of cerebellar circuits in a predictive, but less in a reactive, mode of fingertip force control during manipulative behavior.

Citing Articles

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References

Johansson R, Westling G . Programmed and triggered actions to rapid load changes during precision grip. Exp Brain Res. 1988; 71(1):72-86. DOI: 10.1007/BF00247523. View

Milak M, Shimansky Y, Bracha V, Bloedel J . Effects of inactivating individual cerebellar nuclei on the performance and retention of an operantly conditioned forelimb movement. J Neurophysiol. 1997; 78(2):939-59. DOI: 10.1152/jn.1997.78.2.939. View

Wolpert D, Miall R, Kawato M . Internal models in the cerebellum. Trends Cogn Sci. 2011; 2(9):338-47. DOI: 10.1016/s1364-6613(98)01221-2. View

Fellows S, Ernst J, Schwarz M, Topper R, Noth J . Precision grip deficits in cerebellar disorders in man. Clin Neurophysiol. 2001; 112(10):1793-802. DOI: 10.1016/s1388-2457(01)00623-x. View

Wolpert D, Flanagan J . Motor prediction. Curr Biol. 2001; 11(18):R729-32. DOI: 10.1016/s0960-9822(01)00432-8. View

Stein J, Glickstein M . Role of the cerebellum in visual guidance of movement. Physiol Rev. 1992; 72(4):967-1017. DOI: 10.1152/physrev.1992.72.4.967. View

Mason C, Miller L, Baker J, Houk J . Organization of reaching and grasping movements in the primate cerebellar nuclei as revealed by focal muscimol inactivations. J Neurophysiol. 1998; 79(2):537-54. DOI: 10.1152/jn.1998.79.2.537. View

Rao S, Harrington D, Haaland K, Bobholz J, Cox R, Binder J . Distributed neural systems underlying the timing of movements. J Neurosci. 1997; 17(14):5528-35. PMC: 6793838. View

Macefield V, Johansson R . Loads applied tangential to a fingertip during an object restraint task can trigger short-latency as well as long-latency EMG responses in hand muscles. Exp Brain Res. 2003; 152(2):143-9. DOI: 10.1007/s00221-003-1421-9. View

10.

Diener H, Dichgans J . Pathophysiology of cerebellar ataxia. Mov Disord. 1992; 7(2):95-109. DOI: 10.1002/mds.870070202. View

11.

Smith A, Dugas C, FORTIER P, Kalaska J, Picard N . Comparing cerebellar and motor cortical activity in reaching and grasping. Can J Neurol Sci. 1993; 20 Suppl 3:S53-61. View

12.

Nowak D, Hermsdorfer J, Marquardt C . Grip and load force coupling during discrete vertical arm movements with a grasped object in cerebellar atrophy. Exp Brain Res. 2002; 145(1):28-39. DOI: 10.1007/s00221-002-1079-8. View

13.

Espinoza E, Smith A . Purkinje cell simple spike activity during grasping and lifting objects of different textures and weights. J Neurophysiol. 1990; 64(3):698-714. DOI: 10.1152/jn.1990.64.3.698. View

14.

ROBERTSON L, GRIMM R . Responses of primate dentate neurons to different trajectories of the limb. Exp Brain Res. 1975; 23(5):447-62. DOI: 10.1007/BF00234914. View

15.

Serrien D, WIESENDANGER M . Grip-load force coordination in cerebellar patients. Exp Brain Res. 1999; 128(1-2):76-80. DOI: 10.1007/s002210050820. View

16.

HOOVER J, Strick P . The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1. J Neurosci. 1999; 19(4):1446-63. PMC: 6786031. View

17.

Bastian A, Martin T, Keating J, Thach W . Cerebellar ataxia: abnormal control of interaction torques across multiple joints. J Neurophysiol. 1996; 76(1):492-509. DOI: 10.1152/jn.1996.76.1.492. View

18.

Hermsdorfer J, Wessel K, Mai N, Marquardt C . Perturbation of precision grip in Friedreich's ataxia and late-onset cerebellar ataxia. Mov Disord. 1994; 9(6):650-4. DOI: 10.1002/mds.870090611. View

19.

Lang C, Bastian A . Additional somatosensory information does not improve cerebellar adaptation during catching. Clin Neurophysiol. 2001; 112(5):895-907. DOI: 10.1016/s1388-2457(01)00518-1. View

20.

Matthews P . The human stretch reflex and the motor cortex. Trends Neurosci. 1991; 14(3):87-91. DOI: 10.1016/0166-2236(91)90064-2. View