Distribution of Subclasses MefA and MefE of the MefA Gene Among Clinical Isolates of Macrolide-resistant (M-phenotype) Streptococcus Pneumoniae, Viridans Group Streptococci, and Streptococcus Pyogenes

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2005 Jan 28

PMID 15673780

Citations 9

Authors

Carmen Ardanuy

Fe Tubau

Josefina Linares

Maria Angeles Dominguez

Roman Pallares

Rogelio Martin

Affiliations

Soon will be listed here.

Abstract

The distribution of subclasses mefA and mefE of the mefA gene among 116 M-phenotype streptococci was as follows: pneumococci (38 strains had mefE and 4 mefA), viridans streptococci (49 mefE and 1 mefA), and Streptococcus pyogenes (24 mefA). Spain(9V)-3-14 and England(14)-9 clones of serotype 14 were dominant among pneumococci.

Citing Articles

Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics.

Schmartz G, Rehner J, Gund M, Keller V, Molano L, Rupf S Nat Commun. 2024; 15(1):8261.

PMID: 39327438 PMC: 11427559. DOI: 10.1038/s41467-024-52598-7.

An Overview of Macrolide Resistance in Streptococci: Prevalence, Mobile Elements and Dynamics.

Berbel D, Gonzalez-Diaz A, Lopez de Egea G, Camara J, Ardanuy C Microorganisms. 2022; 10(12).

PMID: 36557569 PMC: 9783990. DOI: 10.3390/microorganisms10122316.

Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture.

Caselli E, Fabbri C, DAccolti M, Soffritti I, Bassi C, Mazzacane S BMC Microbiol. 2020; 20(1):120.

PMID: 32423437 PMC: 7236360. DOI: 10.1186/s12866-020-01801-y.

Antibiotic Resistance Patterns and Related Mobile Genetic Elements of Pneumococci and β-Hemolytic Streptococci in Thai Healthy Children.

Tantivitayakul P, Lapirattanakul J, Vichayanrat T, Muadchiengka T Indian J Microbiol. 2016; 56(4):417-425.

PMID: 27784937 PMC: 5061698. DOI: 10.1007/s12088-016-0607-3.

Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae.

Figueira M, Fernandes P, Pelton S Antimicrob Agents Chemother. 2016; 60(9):5533-8.

PMID: 27401563 PMC: 4997842. DOI: 10.1128/AAC.00863-16.

References

Marimon J, Iglesias L, Vicente D, Perez-Trallero E . Molecular characterization of erythromycin-resistant clinical isolates of the four major antimicrobial-resistant Spanish clones of Streptococcus pneumoniae (Spain23F-1, Spain6B-2, Spain9V-3, and Spain14-5). Microb Drug Resist. 2003; 9(2):133-7. DOI: 10.1089/107662903765826714. View

Coffey T, Daniels M, Enright M, Spratt B . Serotype 14 variants of the Spanish penicillin-resistant serotype 9V clone of Streptococcus pneumoniae arose by large recombinational replacements of the cpsA-pbp1a region. Microbiology (Reading). 1999; 145 ( Pt 8):2023-2031. DOI: 10.1099/13500872-145-8-2023. View

Arpin C, Canron M, Maugein J, Quentin C . Incidence of mefA and mefE genes in viridans group streptococci. Antimicrob Agents Chemother. 1999; 43(9):2335-6. PMC: 89477. DOI: 10.1128/AAC.43.9.2335. View

Roberts M, Sutcliffe J, Courvalin P, Jensen L, Rood J, Seppala H . Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. Antimicrob Agents Chemother. 1999; 43(12):2823-30. PMC: 89572. DOI: 10.1128/AAC.43.12.2823. View

Granizo J, Aguilar L, Casal J, Garcia-Rey C, Dal-Re R, Baquero F . Streptococcus pneumoniae resistance to erythromycin and penicillin in relation to macrolide and beta-lactam consumption in Spain (1979-1997). J Antimicrob Chemother. 2000; 46(5):767-73. DOI: 10.1093/jac/46.5.767. View

Seral C, Castillo F, Rubio-Calvo M, Fenoll A, Garcia C, Gomez-Lus R . Distribution of resistance genes tet(M), aph3'-III, catpC194 and the integrase gene of Tn1545 in clinical Streptococcus pneumoniae harbouring erm(B) and mef(A) genes in Spain. J Antimicrob Chemother. 2001; 47(6):863-6. DOI: 10.1093/jac/47.6.863. View

McGee L, McDougal L, Zhou J, Spratt B, Tenover F, George R . Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network. J Clin Microbiol. 2001; 39(7):2565-71. PMC: 88185. DOI: 10.1128/JCM.39.7.2565-2571.2001. View

Perez-Trallero E, Vicente D, Montes M, Marimon J, Pineiro L . High proportion of pharyngeal carriers of commensal streptococci resistant to erythromycin in Spanish adults. J Antimicrob Chemother. 2001; 48(2):225-9. DOI: 10.1093/jac/48.2.225. View

Del Grosso M, Iannelli F, Messina C, Santagati M, Petrosillo N, Stefani S . Macrolide efflux genes mef(A) and mef(E) are carried by different genetic elements in Streptococcus pneumoniae. J Clin Microbiol. 2002; 40(3):774-8. PMC: 120261. DOI: 10.1128/JCM.40.3.774-778.2002. View

10.

Gordon K, Beach M, Biedenbach D, Jones R, Rhomberg P, Mutnick A . Antimicrobial susceptibility patterns of beta-hemolytic and viridans group streptococci: report from the SENTRY Antimicrobial Surveillance Program (1997-2000). Diagn Microbiol Infect Dis. 2002; 43(2):157-62. DOI: 10.1016/s0732-8893(02)00374-7. View

11.

Amezaga M, Carter P, Cash P, McKenzie H . Molecular epidemiology of erythromycin resistance in Streptococcus pneumoniae isolates from blood and noninvasive sites. J Clin Microbiol. 2002; 40(9):3313-8. PMC: 130757. DOI: 10.1128/JCM.40.9.3313-3318.2002. View

12.

Facklam R . What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin Microbiol Rev. 2002; 15(4):613-30. PMC: 126867. DOI: 10.1128/CMR.15.4.613-630.2002. View

13.

Montanari M, Mingoia M, Cochetti I, Varaldo P . Phenotypes and genotypes of erythromycin-resistant pneumococci in Italy. J Clin Microbiol. 2003; 41(1):428-31. PMC: 149635. DOI: 10.1128/JCM.41.1.428-431.2003. View

14.

Fotopoulou N, Tassios P, Beste D, Ioannidou S, Efstratiou A, Lawrence E . A common clone of erythromycin-resistant Streptococcus pneumoniae in Greece and the UK. Clin Microbiol Infect. 2003; 9(9):924-9. DOI: 10.1046/j.1469-0691.2003.00689.x. View

15.

Del Grosso M, Scotto dAbusco A, Iannelli F, Pozzi G, Pantosti A . Tn2009, a Tn916-like element containing mef(E) in Streptococcus pneumoniae. Antimicrob Agents Chemother. 2004; 48(6):2037-42. PMC: 415626. DOI: 10.1128/AAC.48.6.2037-2042.2004. View

16.

Soares S, Kristinsson K, Musser J, Tomasz A . Evidence for the introduction of a multiresistant clone of serotype 6B Streptococcus pneumoniae from Spain to Iceland in the late 1980s. J Infect Dis. 1993; 168(1):158-63. DOI: 10.1093/infdis/168.1.158. View

17.

Tenover F, Arbeit R, Goering R, Mickelsen P, Murray B, Persing D . Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995; 33(9):2233-9. PMC: 228385. DOI: 10.1128/jcm.33.9.2233-2239.1995. View

18.

Hall L, Whiley R, Duke B, George R, Efstratiou A . Genetic relatedness within and between serotypes of Streptococcus pneumoniae from the United Kingdom: analysis of multilocus enzyme electrophoresis, pulsed-field gel electrophoresis, and antimicrobial resistance patterns. J Clin Microbiol. 1996; 34(4):853-9. PMC: 228905. DOI: 10.1128/jcm.34.4.853-859.1996. View

19.

Sutcliffe J, Tait-Kamradt A, Wondrack L . Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. Antimicrob Agents Chemother. 1996; 40(8):1817-24. PMC: 163423. DOI: 10.1128/AAC.40.8.1817. View

20.

Sutcliffe J, Grebe T, Tait-Kamradt A, Wondrack L . Detection of erythromycin-resistant determinants by PCR. Antimicrob Agents Chemother. 1996; 40(11):2562-6. PMC: 163576. DOI: 10.1128/AAC.40.11.2562. View