Directing Cell Migration with Asymmetric Micropatterns

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2005 Jan 18

PMID 15653772

Citations 108

Authors

Xingyu Jiang

Derek A Bruzewicz

Amy P Wong

Matthieu Piel

George M Whitesides

Affiliations

Soon will be listed here.

Abstract

This report shows that the direction of polarization of attached mammalian cells determines the direction in which they move. Surfaces micropatterned with appropriately functionalized self-assembled monolayers constrain individual cells to asymmetric geometries (for example, a teardrop); these geometries polarize the morphology of the cell. After electrochemical desorption of the self-assembled monolayers removes these constraints and allows the cells to move across the surface, they move toward their blunt ends.

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