How Do Microtubules Guide Migrating Cells?

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2002 Dec 4

PMID 12461561

Citations 72

Authors

J Victor Small

Benjamin Geiger

Irina Kaverina

Alexander Bershadsky

Affiliations

Soon will be listed here.

Abstract

Microtubules have long been implicated in the polarization of migrating cells, but how they carry out this role is unclear. Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility.

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