The Transcription Factor Gene Nfib is Essential for Both Lung Maturation and Brain Development

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 2005 Jan 6

PMID 15632069

Citations 142

Authors

George Steele-Perkins

Celine Plachez

Kenneth G Butz

Guanhu Yang

Cindy J Bachurski

Stephen L Kinsman

E David Litwack

Linda J Richards

Richard M Gronostajski

Affiliations

Soon will be listed here.

Abstract

The phylogenetically conserved nuclear factor I (NFI) gene family encodes site-specific transcription factors essential for the development of a number of organ systems. We showed previously that Nfia-deficient mice exhibit agenesis of the corpus callosum and other forebrain defects, whereas Nfic-deficient mice have agenesis of molar tooth roots and severe incisor defects. Here we show that Nfib-deficient mice possess unique defects in lung maturation and exhibit callosal agenesis and forebrain defects that are similar to, but more severe than, those seen in Nfia-deficient animals. In addition, loss of Nfib results in defects in basilar pons formation and hippocampus development that are not seen in Nfia-deficient mice. Heterozygous Nfib-deficient animals also exhibit callosal agenesis and delayed lung maturation, indicating haploinsufficiency at the Nfib locus. The similarity in brain defects in Nfia- and Nfib-deficient animals suggests that these two genes may cooperate in late fetal forebrain development, while Nfib is essential for late fetal lung maturation and development of the pons.

Citing Articles

Mapping the regulatory effects of common and rare non-coding variants across cellular and developmental contexts in the brain and heart.

Marderstein A, Kundu S, Padhi E, Deshpande S, Wang A, Robb E bioRxiv. 2025; .

PMID: 40027628 PMC: 11870466. DOI: 10.1101/2025.02.18.638922.

Origin and stepwise evolution of vertebrate lungs.

Li Y, Hu M, Zhang Z, Wu B, Zheng J, Zhang F Nat Ecol Evol. 2025; .

PMID: 39953253 DOI: 10.1038/s41559-025-02642-6.

Single-cell transcriptome atlas of male mouse pituitary across postnatal life highlighting its stem cell landscape.

De Vriendt S, Laporte E, Abayli B, Hoekx J, Hermans F, Lambrechts D iScience. 2025; 28(2):111708.

PMID: 39898054 PMC: 11787594. DOI: 10.1016/j.isci.2024.111708.

Nuclear Factor I Family Members are Key Transcription Factors Regulating Gene Expression.

Malaymar Pinar D, Goos H, Tan Z, Kumpula E, Chowdhury I, Wang Z Mol Cell Proteomics. 2024; 24(1):100890.

PMID: 39617063 PMC: 11775196. DOI: 10.1016/j.mcpro.2024.100890.

Activating Invasion and Metastasis in Small Cell Lung Cancer: Role of the Tumour Immune Microenvironment and Mechanisms of Vasculogenesis, Epithelial-Mesenchymal Transition, Cell Migration, and Organ Tropism.

He C Cancer Rep (Hoboken). 2024; 7(10):e70018.

PMID: 39376011 PMC: 11458887. DOI: 10.1002/cnr2.70018.

References

Gronostajski R . Roles of the NFI/CTF gene family in transcription and development. Gene. 2000; 249(1-2):31-45. DOI: 10.1016/s0378-1119(00)00140-2. View

Costa R, Kalinichenko V, Lim L . Transcription factors in mouse lung development and function. Am J Physiol Lung Cell Mol Physiol. 2001; 280(5):L823-38. DOI: 10.1152/ajplung.2001.280.5.L823. View

Shu T, Richards L . Cortical axon guidance by the glial wedge during the development of the corpus callosum. J Neurosci. 2001; 21(8):2749-58. PMC: 6762517. View

Glasser S, Burhans M, Korfhagen T, Na C, Sly P, Ross G . Altered stability of pulmonary surfactant in SP-C-deficient mice. Proc Natl Acad Sci U S A. 2001; 98(11):6366-71. PMC: 33474. DOI: 10.1073/pnas.101500298. View

Gesemann M, Litwack E, Yee K, Christen U, OLeary D . Identification of candidate genes for controlling development of the basilar pons by differential display PCR. Mol Cell Neurosci. 2001; 18(1):1-12. DOI: 10.1006/mcne.2001.0996. View

Stiles A, Chrysis D, Jarvis H, Brighton B . Programmed cell death in normal fetal rat lung development. Exp Lung Res. 2001; 27(7):569-87. DOI: 10.1080/019021401753181836. View

Xian J, Clark K, Fordham R, Pannell R, Rabbitts T, Rabbitts P . Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc Natl Acad Sci U S A. 2001; 98(26):15062-6. PMC: 64983. DOI: 10.1073/pnas.251407098. View

Richards L . Surrounded by Slit--how forebrain commissural axons can be led astray. Neuron. 2002; 33(2):153-5. DOI: 10.1016/s0896-6273(02)00566-4. View

Grunder A, Ebel T, Mallo M, Schwarzkopf G, Shimizu T, Sippel A . Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002; 112(1-2):69-77. DOI: 10.1016/s0925-4773(01)00640-2. View

10.

Kralovics R, Guan Y, Prchal J . Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera. Exp Hematol. 2002; 30(3):229-36. DOI: 10.1016/s0301-472x(01)00789-5. View

11.

Lu M, Grove E, Miller R . Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci U S A. 2002; 99(10):7090-5. PMC: 124533. DOI: 10.1073/pnas.092013799. View

12.

Forster E, Tielsch A, Saum B, Weiss K, Johanssen C, Graus-Porta D . Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. Proc Natl Acad Sci U S A. 2002; 99(20):13178-83. PMC: 130606. DOI: 10.1073/pnas.202035899. View

13.

Prodhan P, Kinane T . Developmental paradigms in terminal lung development. Bioessays. 2002; 24(11):1052-9. DOI: 10.1002/bies.10177. View

14.

Shi W, Heisterkamp N, Groffen J, Zhao J, Warburton D, Kaartinen V . TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids. Am J Physiol. 1999; 277(6):L1205-13. DOI: 10.1152/ajplung.1999.277.6.L1205. View

15.

Galceran J, Devaney E, Rubenstein J, Grosschedl R . Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development. 2000; 127(3):469-82. DOI: 10.1242/dev.127.3.469. View

16.

Liu M, Pleasure S, Collins A, Noebels J, Naya F, Tsai M . Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc Natl Acad Sci U S A. 2000; 97(2):865-70. PMC: 15422. DOI: 10.1073/pnas.97.2.865. View

17.

Ben-Arie N, Hassan B, Bermingham N, Malicki D, Armstrong D, Matzuk M . Functional conservation of atonal and Math1 in the CNS and PNS. Development. 2000; 127(5):1039-48. DOI: 10.1242/dev.127.5.1039. View

18.

Bouwman P, Gollner H, Elsasser H, Eckhoff G, Karis A, Grosveld F . Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000; 19(4):655-61. PMC: 305603. DOI: 10.1093/emboj/19.4.655. View

19.

Warburton D, Schwarz M, Tefft D, Anderson K, Cardoso W . The molecular basis of lung morphogenesis. Mech Dev. 2000; 92(1):55-81. DOI: 10.1016/s0925-4773(99)00325-1. View

20.

Savaskan N, Alvarez-Bolado G, Glumm R, Nitsch R, Skutella T, Heimrich B . Impaired postnatal development of hippocampal neurons and axon projections in the Emx2-/- mutants. J Neurochem. 2002; 83(5):1196-207. DOI: 10.1046/j.1471-4159.2002.01233.x. View