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The Reaction Between Nitrite and Hemoglobin: the Role of Nitrite in Hemoglobin-mediated Hypoxic Vasodilation

Overview
Journal J Inorg Biochem
Specialty Biochemistry
Date 2004 Dec 16
PMID 15598504
Citations 43
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Abstract

The reaction between nitrite and hemoglobin has been studied for over a century. However, recent evidence indicating nitrite is a latent vasodilatory agent that can be activated by its reaction with deoxyhemoglobin has led to renewed interest in this reaction. In this review we survey, in the context of our own recent studies, the chemical reactivity of nitrite with oxyhemoglobin, deoxyhemoglobin and methemoglobin, and place these reactions in both a physiological and pharmacological/therapeutic context.

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