» Articles » PMID: 15554416

Management of Patients with Fulminant Hepatic Failure and Brain Edema

Overview
Journal Metab Brain Dis
Publisher Springer
Specialties Endocrinology
Neurology
Date 2004 Nov 24
PMID 15554416
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

Cerebral edema in acute liver failure is associated with a poor prognosis. Optimization of cerebral perfusion pressure and blood flow plays a key role in contemporary management of these patients. However, understanding of the pathophysiology of brain edema is required for optimal patient management. This review explains the relationships between cerebral perfusion and edema and summarizes therapies that are currently used in patients with acute liver failure to prevent and reduce intracranial pressure.

Citing Articles

Toxic Metabolites and Inborn Errors of Amino Acid Metabolism: What One Informs about the Other.

Lee N, Kim D Metabolites. 2022; 12(6).

PMID: 35736461 PMC: 9231173. DOI: 10.3390/metabo12060527.


Living Donor Liver Transplantation in Acute Liver Failure Patients with Grade IV Encephalopathy: Is Deep Hepatic Coma Still an Absolute Contraindication? A Successful Single-Center Experience.

Yang H, Thorat A, Jeng L, Hsu S, Li P, Yeh C Ann Transplant. 2018; 23:176-181.

PMID: 29531210 PMC: 6248027.


Decompressive craniectomy in neurocritical care.

Chu S, Sheth K Curr Treat Options Neurol. 2015; 17(2):330.

PMID: 25619535 DOI: 10.1007/s11940-014-0330-5.


Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy.

Rao K, Norenberg M Neurochem Int. 2011; 60(7):697-706.

PMID: 21989389 PMC: 4714837. DOI: 10.1016/j.neuint.2011.09.007.


Mild hypothermia does not affect liver regeneration after partial hepatectomy in mice.

Arab J, Pizarro M, Solis N, Sun H, Thevananther S, Arrese M Liver Int. 2008; 29(3):344-8.

PMID: 18662277 PMC: 2859296. DOI: 10.1111/j.1478-3231.2008.01834.x.


References
1.
Shawcross D, Davies N, Mookerjee R, Hayes P, Williams R, Lee A . Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe encephalopathy. Hepatology. 2004; 39(2):471-5. DOI: 10.1002/hep.20044. View

2.
Rao K, Norenberg M . Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia. Metab Brain Dis. 2001; 16(1-2):67-78. DOI: 10.1023/a:1011666612822. View

3.
Munoz S . Difficult management problems in fulminant hepatic failure. Semin Liver Dis. 1993; 13(4):395-413. DOI: 10.1055/s-2007-1007368. View

4.
Larsen F, Gottstein J, Blei A . Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema. J Hepatol. 2001; 34(4):548-54. DOI: 10.1016/s0168-8278(00)00069-6. View

5.
Blei A, Larsen F . Pathophysiology of cerebral edema in fulminant hepatic failure. J Hepatol. 1999; 31(4):771-6. DOI: 10.1016/s0168-8278(99)80361-4. View