Tregs and Transplantation Tolerance

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2004 Nov 17

PMID 15545987

Citations 72

Authors

Patrick T Walsh

Devon K Taylor

Laurence A Turka

Affiliations

Soon will be listed here.

Abstract

The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes specific unresponsiveness to donor alloantigens. This review outlines our current understanding of the Treg subsets that contribute to allotolerance and the mechanisms by which these cells exert their effects as well as their potential for therapy.

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References

Chen Z, Cobbold S, Waldmann H, Metcalfe S . Amplification of natural regulatory immune mechanisms for transplantation tolerance. Transplantation. 1996; 62(9):1200-6. DOI: 10.1097/00007890-199611150-00002. View

Wells A, Li X, Li Y, Walsh M, Zheng X, Wu Z . Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med. 1999; 5(11):1303-7. DOI: 10.1038/15260. View

Qin S, Cobbold S, Pope H, Elliott J, Kioussis D, Davies J . "Infectious" transplantation tolerance. Science. 1993; 259(5097):974-7. DOI: 10.1126/science.8094901. View

Scully R, Qin S, Cobbold S, Waldmann H . Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol. 1994; 24(10):2383-92. DOI: 10.1002/eji.1830241019. View

Suri-Payer E, CANTOR H . Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. J Autoimmun. 2001; 16(2):115-23. DOI: 10.1006/jaut.2000.0473. View

Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N . Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000; 192(2):303-10. PMC: 2193248. DOI: 10.1084/jem.192.2.303. View

Waldmann H, Cobbold S . Regulating the immune response to transplants. a role for CD4+ regulatory cells?. Immunity. 2001; 14(4):399-406. DOI: 10.1016/s1074-7613(01)00120-0. View

Lechler R, Garden O, Turka L . The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol. 2003; 3(2):147-58. DOI: 10.1038/nri1002. View

Hancock W, Sayegh M, Kwok C, Weiner H, Carpenter C . Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation. Transplantation. 1993; 55(5):1112-8. DOI: 10.1097/00007890-199305000-00034. View

10.

Stassen M, Schmitt E, Jonuleit H . Human CD(4+)CD(25+) regulatory T cells and infectious tolerance. Transplantation. 2004; 77(1 Suppl):S23-5. DOI: 10.1097/00007890-200401151-00009. View

11.

Takahashi T, KUNIYASU Y, Toda M, Sakaguchi N, Itoh M, Iwata M . Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol. 1999; 10(12):1969-80. DOI: 10.1093/intimm/10.12.1969. View

12.

Niimi M, Shirasugi N, Ikeda Y, Wood K . Oral antigen induces allograft survival by linked suppression via the indirect pathway. Transplant Proc. 2001; 33(1-2):81. DOI: 10.1016/s0041-1345(00)01913-8. View

13.

Davies J, Leong L, Mellor A, Cobbold S, Waldmann H . T cell suppression in transplantation tolerance through linked recognition. J Immunol. 1996; 156(10):3602-7. View

14.

Sayegh M, Khoury S, Hancock W, Weiner H, Carpenter C . Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat. Proc Natl Acad Sci U S A. 1992; 89(16):7762-6. PMC: 49791. DOI: 10.1073/pnas.89.16.7762. View

15.

Dieckmann D, Bruett C, Ploettner H, Lutz M, Schuler G . Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J Exp Med. 2002; 196(2):247-53. PMC: 2193931. DOI: 10.1084/jem.20020642. View

16.

Kilshaw P, Brent L, Pinto M . Suppressor T cells in mice made unresponsive to skin allografts. Nature. 1975; 255(5508):489-91. DOI: 10.1038/255489a0. View

17.

Sykes M . Mixed chimerism and transplant tolerance. Immunity. 2001; 14(4):417-24. DOI: 10.1016/s1074-7613(01)00122-4. View

18.

Steinman R, Hawiger D, Nussenzweig M . Tolerogenic dendritic cells. Annu Rev Immunol. 2003; 21:685-711. DOI: 10.1146/annurev.immunol.21.120601.141040. View

19.

Graca L, Cobbold S, Waldmann H . Identification of regulatory T cells in tolerated allografts. J Exp Med. 2002; 195(12):1641-6. PMC: 2193557. DOI: 10.1084/jem.20012097. View

20.

Zhang Z, Yang L, Young K, DuTemple B, Zhang L . Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression. Nat Med. 2000; 6(7):782-9. DOI: 10.1038/77513. View