The Brain-derived Neurotrophic Factor Val66met Polymorphism and Variation in Human Cortical Morphology

Overview

Journal J Neurosci

Specialty Neurology

Date 2004 Nov 13

PMID 15537879

Citations 375

Authors

Lukas Pezawas

Beth A Verchinski

Venkata S Mattay

Joseph H Callicott

Bhaskar S Kolachana

Richard E Straub

Michael F Egan

Andreas Meyer-Lindenberg

Daniel R Weinberger

Affiliations

Soon will be listed here.

Abstract

A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.

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