Improved Functional Outcome After Spinal Cord Injury in INOS-deficient Mice

Overview

Journal Spinal Cord

Specialty Neurology

Date 2004 Nov 3

PMID 15520837

Citations 18

Authors

J Isaksson

M Farooque

Y Olsson

Affiliations

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Abstract

Study Design: Functional outcome was evaluated following experimental compression-type spinal cord injury (SCI) in wild-type mice and knockout mice, lacking the inducible nitric oxide synthase (iNOS) gene.

Objectives: To evaluate the role of the nitric oxide generating enzyme iNOS in SCI.

Methods: The experimental animals were subjected to an extradural compression of the thoracic spinal cord. Functional outcome was studied during the first 2 weeks post-injury using a scoring system for assessment of hind limb motor function.

Results: Injury resulted in initial paraplegia followed by gradual improvement of motor function in most cases. Mice lacking the iNOS gene (iNOS-/-) clearly tended to have a better functional outcome than wild-type mice. The difference was significant on day 14 after injury.

Conclusion: In accordance with a few earlier experimental studies, showing beneficial effects of pharmacological iNOS inhibition, the present report would indicate a destructive influence of iNOS following spinal cord trauma.

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