Significant Correlation Between Cerebrospinal Fluid Nitric Oxide Concentrations and Neurologic Prognosis in Incomplete Cervical Cord Injury

Overview

Journal Eur Spine J

Specialty Orthopedics

Date 2007 Aug 23

PMID 17712576

Citations 4

Authors

Noboru Hosaka

Shinji Kimura

Akiyoshi Yamazaki

Xianjun Wang

Hiroshi Denda

Takui Ito

Toru Hirano

Naoto Endo

Affiliations

Soon will be listed here.

Abstract

In animal models of spinal cord injury (SCI), inducible NO (nitric oxide) synthase is expressed in the spinal cord immediately after sustaining SCI. Excessive NO production has cytotoxic effects and induces neuronal apoptosis, causing neural degeneration and neurodysfunction in the spinal cord. Little is known, however, about the relationship between NO(x) (NO metabolites: nitrite and nitrate) levels in the cerebrospinal fluid (CSF) and neurologic severity or recovery in clinical cases. The objective of the present study was to examine the correlation between CSF NO(x) levels and neurologic severity or recovery in SCI. Twenty-five patients with incomplete cervical cord injury (CCI) were examined. Eight cases were treated conservatively (non-operated group). Seventeen cases underwent surgical intervention (operated group). NO(x) levels in the CSF were measured using the Griess method. The severity of the neurologic impairment was assessed using Frankel's classification and the American Spinal Injury Association motor score (ASIA MS). The degree of neurologic recovery was assessed using Frankel's classification and the ASIA motor recovery percentage (MRP). There was no significant difference in the NO(x) levels between the CCI group (NO(x) levels: 5.9 +/- 0.7 microM) and the 36 control subjects (1 volunteer and 35 patients without neurologic disorders, NO(x) levels: 4.9 +/- 0.3 microM). There was no significant difference in NO(x) levels and MRP between the non-operated group and the operated group. The NO(x) levels in total SCI group were significantly correlated with the ASIA MS and MRP. There was a significant correlation between CSF NO(x) levels and neurologic severity or recovery in incomplete CCI.

Citing Articles

Nitric Oxide Metabolite Concentration in Cerebrospinal Fluid: Useful as a Prognostic Marker?.

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Oxidative stress and antioxidative parameters in patients with spinal cord injury: implications in the pathogenesis of disease.

Fatima G, Sharma V, Das S, Mahdi A Spinal Cord. 2014; 53(1):3-6.

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A Rehabilomics framework for personalized and translational rehabilitation research and care for individuals with disabilities: Perspectives and considerations for spinal cord injury.

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Clinical significance of cerebrospinal fluid nitric oxide concentrations in degenerative cervical and lumbar diseases.

Denda H, Kimura S, Yamazaki A, Hosaka N, Takano Y, Imura K Eur Spine J. 2010; 20(4):604-11.

PMID: 21190044 PMC: 3065603. DOI: 10.1007/s00586-010-1663-8.

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