Mutation of a Single Lytic Transglycosylase Causes Aberrant Septation and Inhibits Cell Separation of Neisseria Gonorrhoeae

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2004 Nov 2

PMID 15516597

Citations 34

Authors

Karen A Cloud

Joseph P Dillard

Affiliations

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Abstract

The function of lytic peptidoglycan transglycosylases is poorly understood. Single lytic transglycosylase mutants of Escherichia coli have no growth phenotype. By contrast, mutation of Neisseria gonorrhoeae ltgC inhibited cell separation without affecting peptidoglycan monomer production. Thus, LtgC has a dedicated function in gonococcal cell division.

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