Colonic Mucosal Mast Cell Distribution at Line of Demarcation of Active Ulcerative Colitis

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1992 Apr 11

PMID 1551335

Citations 28

Authors

T King

W Biddle

P Bhatia

J Moore

P B Miner Jr

Affiliations

Soon will be listed here.

Abstract

We examined the distribution of colonic mucosal mast cells in 25 patients with active ulcerative colitis, with a clear line of demarcation separating active inflammation from normal mucosa. Biopsies, at least one adjacent to the line of demarcation, one in inflamed mucosa, and one above were obtained during colonoscopy. Eight patients had elevated mast cells throughout the colon, and 12 had increased numbers at the line of demarcation of disease. Mean numbers of mast cells from these patients were 6.3 (+/- 2.1 SD) in active inflammation, 19.5 (+/- 7.1 SD) at the line of demarcation, and 15.8 (+/- 8.4 SD) in normal mucosa. Histologic inflammation decreased as mast cells increased. The accumulation of mast cells at the visible line of demarcation between normal and abnormal mucosa suggests mast cells play a critical role in either accelerating the process of inflammation or in suppressing continued extension of the disease.

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References

Szegli G, Herold A, Negut E, Bucurenci N, Mazilu E, ARION R . Clinical efficacy of a new antiinflammatory drug with free radicals scavenging properties: superoxide dismutase (SOD) and catalase of human origin. Arch Roum Pathol Exp Microbiol. 1986; 45(1):75-89. View

Dallegri F, Ottonello L, Ballestrero A, Bogliolo F, Ferrando F, Patrone F . Cytoprotection against neutrophil derived hypochlorous acid: a potential mechanism for the therapeutic action of 5-aminosalicylic acid in ulcerative colitis. Gut. 1990; 31(2):184-6. PMC: 1378377. DOI: 10.1136/gut.31.2.184. View

Dull B, Salata K, Van Langenhove A, Goldman P . 5-Aminosalicylate: oxidation by activated leukocytes and protection of cultured cells from oxidative damage. Biochem Pharmacol. 1987; 36(15):2467-72. DOI: 10.1016/0006-2952(87)90518-1. View

Dvorak A, Monahan R . Crohn's disease--mast cell quantitation using one micron plastic sections for light microscopic study. Pathol Annu. 1983; 18 Pt 1:181-90. View

Baum C, Bhatia P, Miner Jr P . Increased colonic mucosal mast cells associated with severe watery diarrhea and microscopic colitis. Dig Dis Sci. 1989; 34(9):1462-5. DOI: 10.1007/BF01538086. View

HIATT R, Katz L . Mast cells in inflammatory conditions of the gastrointestinal tract. Am J Gastroenterol. 1962; 37:541-5. View

BERCOVITZ Z, SOMMERS S . Altered inflammatory reaction in nonspecific ulcerative colitis. Arch Intern Med. 1966; 117(4):504-10. View

Dileepan K, Simpson K, Stechschulte D . Modulation of macrophage superoxide-induced cytochrome c reduction by mast cells. J Lab Clin Med. 1989; 113(5):577-85. View

Goldsmith P, McGarity B, Walls A, Church M, Robertson D . Corticosteroid treatment reduces mast cell numbers in inflammatory bowel disease. Dig Dis Sci. 1990; 35(11):1409-13. DOI: 10.1007/BF01536749. View

10.

RANLOV P, Nielsen M, WANSTRUP J . Ultrastructure of the ileum in Crohn's disease. Immune lesions and mastocytosis. Scand J Gastroenterol. 1972; 7(5):471-6. DOI: 10.3109/00365527209180772. View

11.

Whorwell P, Whorwell G, BAMFORTH J, Colin Jones D, Down P, Edwards A . A double-blind controlled trial of the effect of sodium cromoglycate in preventing relapse in ulcerative colitis. Postgrad Med J. 1981; 57(669):436-8. PMC: 2424968. DOI: 10.1136/pgmj.57.669.436. View

12.

Balazs M, Illyes G, VADASZ G . Mast cells in ulcerative colitis. Quantitative and ultrastructural studies. Virchows Arch B Cell Pathol Incl Mol Pathol. 1989; 57(6):353-60. DOI: 10.1007/BF02899101. View

13.

Sarin S, Malhotra V, SEN GUPTA S, Karol A, Gaur S, Anand B . Significance of eosinophil and mast cell counts in rectal mucosa in ulcerative colitis. A prospective controlled study. Dig Dis Sci. 1987; 32(4):363-7. DOI: 10.1007/BF01296289. View

14.

Ruitenberg E, Gustowska L, Elgersma A, Ruitenberg H . Effect of fixation on the light microscopical visualization of mast cells in the mucosa and connective tissue of the human duodenum. Int Arch Allergy Appl Immunol. 1982; 67(3):233-8. DOI: 10.1159/000233024. View

15.

Strobel S, Miller H, Ferguson A . Human intestinal mucosal mast cells: evaluation of fixation and staining techniques. J Clin Pathol. 1981; 34(8):851-8. PMC: 493957. DOI: 10.1136/jcp.34.8.851. View

16.

Petkau A . Scientific basis for the clinical use of superoxide dismutase. Cancer Treat Rev. 1986; 13(1):17-44. DOI: 10.1016/0305-7372(86)90012-5. View

17.

Lloyd G, Green F, Fox H, Mani V, Turnberg L . Mast cells and immunoglobulin E in inflammatory bowel disease. Gut. 1975; 16(11):861-5. PMC: 1413125. DOI: 10.1136/gut.16.11.861. View

18.

Jenkins D, Goodall A, Scott B . Ulcerative colitis: one disease or two? (Quantitative histological differences between distal and extensive disease). Gut. 1990; 31(4):426-30. PMC: 1378417. DOI: 10.1136/gut.31.4.426. View

19.

Befus D, Goodacre R, Dyck N, Bienenstock J . Mast cell heterogeneity in man. I. Histologic studies of the intestine. Int Arch Allergy Appl Immunol. 1985; 76(3):232-6. DOI: 10.1159/000233697. View

20.

Riley S, Mani V, GOODMAN M, Dutt S, Herd M . Microscopic activity in ulcerative colitis: what does it mean?. Gut. 1991; 32(2):174-8. PMC: 1378803. DOI: 10.1136/gut.32.2.174. View