Synthesis of Small Molecule CDC25 Phosphatases Inhibitors

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2004 Oct 27

PMID 15501045

Citations 6

Authors

Marie-Odile Contour-Galcera

Olivier Lavergne

Marie-Christine Brezak

Bernard Ducommun

Gregoire Prevost

Affiliations

Soon will be listed here.

Abstract

A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.

Citing Articles

A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors.

Abdelwahab A, El-Sawy E, Hanna A, Bagrel D, Kirsch G Molecules. 2022; 27(8).

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Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by one selected derivative in melanoma cells.

Aliotta F, Nasso R, Rullo R, Arcucci A, Avagliano A, Simonetti M J Enzyme Inhib Med Chem. 2020; 35(1):1866-1878.

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Pharmacophore-guided discovery of CDC25 inhibitors causing cell cycle arrest and tumor regression.

Kabakci Z, Kappeli S, Cantu C, Jensen L, Konig C, Toggweiler J Sci Rep. 2019; 9(1):1335.

PMID: 30718768 PMC: 6362118. DOI: 10.1038/s41598-019-38579-7.

Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases.

Evain-Bana E, Schiavo L, Bour C, Lanfranchi D, Berardozzi S, Ghirga F J Enzyme Inhib Med Chem. 2016; 32(1):113-118.

PMID: 27774816 PMC: 6010111. DOI: 10.1080/14756366.2016.1238364.

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Pericolini E, Gabrielli E, Bistoni G, Cenci E, Perito S, Chow S PLoS One. 2010; 5(9):e12720.

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