Platelet--cancer Interactions: Mechanisms and Pharmacology of Tumour Cell-induced Platelet Aggregation

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2004 Oct 20

PMID 15492016

Citations 132

Authors

Paul Jurasz

David Alonso-Escolano

Marek W Radomski

Affiliations

Soon will be listed here.

Abstract

During haematogenous metastasis, cancer cells migrate to the vasculature and interact with platelets resulting in tumour cell-induced platelet aggregation (TCIPA). We review: 1. The biological and clinical significance of TCIPA; 2. Molecular mechanisms involved in platelet aggregation by cancer cells; 3. Strategies for pharmacological regulation of these interactions. We conclude that pharmacological regulation of platelet-cancer cell interactions may reduce the impact of TCIPA on cancer biology.

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