In Vivo MRI Measurement of Blood Oxygen Saturation in Children with Congenital Heart Disease

Overview

Journal Pediatr Radiol

Specialty Pediatrics

Date 2004 Oct 19

PMID 15490150

Citations 12

Authors

Lynne E Nield

Xiu-Ling L Qi

Emanuela R Valsangiacomo

Christopher K Macgowan

Graham A Wright

Lisa K Hornberger

Shi-Joon Yoo

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of this prospective study was to measure in vivo blood oxygen saturation (%O2) by MRI in children with congenital heart disease (CHD) using population-based values for T2O (T2 signal decay of fully oxygenated blood) and K (a parameter representing the deoxyhemoglobin effect) and compare the %O2 with direct cardiac catheterization measurements.

Background: MRI can determine %O2 using in vivo measurement of signal decay (T2) and an in vitro calibration curve relating T2 and %O2, based on the equation: 1/T2 = 1/T2O + K(1-%O2/100)2. Recent studies have correlated the T2/%O2 in children with CHD with the adult calibration statistics.

Methods: A total of ten children (five male, five female) with single ventricle CHD (median age 4.8 months, range 2 months to 4.4 years) undergoing cardiac catheterization were included in the study. The blood T2 measurements for each patient were performed in a 1.5 T GE CV scanner. The %O2 was then calculated based on the equation using values of T2O determined from individual hematocrits, and a population average value of K derived for children. The %O2 values were compared with direct %O2 measurements from cardiac catheterization.

Results: The %O2 values by MRI were strongly correlated with direct cardiac catheterization measurements (R = 0.825; P < 0.001).

Conclusion: The study indicates that the noninvasive measurement of %O2 by MRI can accurately measure oxygen saturation in children with complex CHD.

Citing Articles

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Oxygen Sensing, Hypoxia Tracing and Imaging with Functional Metalloprobes for the Early Detection of Non-communicable Diseases.

Mirabello V, Cortezon-Tamarit F, Pascu S Front Chem. 2018; 6:27.

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CMR-based blood oximetry via multi-parametric estimation using multiple T2 measurements.

Varghese J, Potter L, LaFountain R, Pan X, Raman S, Ahmad R J Cardiovasc Magn Reson. 2017; 19(1):88.

PMID: 29121971 PMC: 5680788. DOI: 10.1186/s12968-017-0403-1.

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