Richard Havel, Howard Eder, and the Evolution of Lipoprotein Analysis

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2004 Oct 19

PMID 15489945

Citations 4

Authors

Scott M Grundy

Affiliations

Soon will be listed here.

Abstract

In 1956, the JCI published a paper by Richard Havel, Howard Eder, and Joseph Bragdon on a method using an ultracentrifuge to physically separate plasma lipoproteins and chemical methods to analyze their lipid constituents. This paper has been much cited (7081 times as of this writing) in part because it represents a solid method that, with various modifications, has been applicable for the study of lipoproteins for almost half a century.

Citing Articles

How the JCI's most-cited paper sparked the field of lipoprotein research.

Brown M, Goldstein J J Clin Invest. 2024; 134(4).

PMID: 38357920 PMC: 10866646. DOI: 10.1172/JCI177475.

The early years of lipoprotein research: from discovery to clinical application.

Siri-Tarino P, Krauss R J Lipid Res. 2016; 57(10):1771-1777.

PMID: 27474223 PMC: 5036374. DOI: 10.1194/jlr.R069575.

Comparison of lipoprotein separation and lipid analysis methodologies for human and cynomolgus monkey plasma samples.

Han S, Flattery A, McLaren D, Raubertas R, Lee S, Mendoza V J Cardiovasc Transl Res. 2011; 5(1):75-83.

PMID: 22194019 DOI: 10.1007/s12265-011-9340-9.

Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size.

van Schalkwijk D, de Graaf A, van Ommen B, Bochove K, Rensen P, Havekes L J Lipid Res. 2009; 50(12):2398-411.

PMID: 19515990 PMC: 2781312. DOI: 10.1194/jlr.M800354-JLR200.

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