Quantitative Trait Loci Affecting Life Span in Replicated Populations of Drosophila Melanogaster. I. Composite Interval Mapping

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 2004 Sep 30

PMID 15454544

Citations 16

Authors

Scott N Forbes

Robert K Valenzuela

Paul Keim

Philip M Service

Affiliations

Soon will be listed here.

Abstract

Composite interval mapping was used to identify life-span QTL in F2 progeny of three crosses between different pairs of inbred lines. Each inbred line was derived from a different outbred population that had undergone long-term selection for either long or short life span. Microsatellite loci were used as genetic markers, and confidence intervals for QTL location were estimated by bootstrapping. A minimum of 10 QTL were detected, nine of which were located on the two major autosomes. Five QTL were present in at least two crosses and five were present in both sexes. Observation of the same QTL in more than one cross was consistent with the hypothesis that genetic variation for life span is maintained by balancing selection. For all QTL except one, allelic effects were in the direction predicted on the basis of outbred source population. Alleles that conferred longer life were always at least partially dominant.

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