Durability of the Sun Protection Factor Provided by Dihydroxyacetone

Overview

Journal Photodermatol Photoimmunol Photomed

Specialties Allergy & Immunology
Dermatology

Date 2004 Sep 24

PMID 15379873

Citations 7

Authors

A Faurschou

H C Wulf

Affiliations

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Abstract

Background/purpose: The sunless tanning agent dihydroxyacetone (DHA) is known to protect against longwave ultraviolet radiation (UVA) and visible light. Recently, our laboratory has shown that DHA in addition offers a modest sun protection factor (SPF) in humans. We conducted this study in order to investigate the durability of the SPF provided by DHA.

Methods: Ten healthy volunteers were treated with 20% DHA cream twice in three areas on the volar forearm. One, 5 and 7 days after the second application the participants were phototested with simulated sunlight in each area. Blue reflectance was used to measure the skin coloration by DHA in the test sites.

Results: DHA generated a significant SPF of 3.0 at day 1, 2.0 at day 5 and 1.7 at day 7 (P<0.0001). The SPF was positively correlated to the change in blue reflectance (r=0.39, P=0.034). The loss of SPF unit/day was not significantly different between the subjects (P<0.122). However, the intercepts were significantly different (P<0.0001) indicating differences in the initial SPF obtained among the subjects.

Conclusions: The SPF of DHA decreases with the same loss of SPF unit/day between humans and the durability of the SPF thus depends on the initial SPF provided.

Citing Articles

Comparison of Color Development Kinetics of Tanning Reactions of Dihydroxyacetone with Free and Protected Basic Amino Acids.

Sun Y, Lee S, Lin L ACS Omega. 2022; 7(49):45510-45517.

PMID: 36530253 PMC: 9753197. DOI: 10.1021/acsomega.2c06124.

In search of the perfect tan: Chemical activity, biological effects, business considerations, and consumer implications of dihydroxyacetone sunless tanning products.

Turner J, OLoughlin D, Green P, McDonald T, Hamill K J Cosmet Dermatol. 2022; 22(1):79-88.

PMID: 35384270 PMC: 10083914. DOI: 10.1111/jocd.14968.

Dihydroxyacetone induces G2/M arrest and apoptotic cell death in A375P melanoma cells.

Smith K, Granberry M, Tan M, Daniel C, Gassman N Environ Toxicol. 2017; 33(3):333-342.

PMID: 29193605 PMC: 5809210. DOI: 10.1002/tox.22520.

Effect of Simultaneous Administration of Dihydroxyacetone on the Diffusion of Lawsone Through Various In Vitro Skin Models.

Munt D, Grana A, Hulce M, Fusaro R, Dash A AAPS PharmSciTech. 2015; 16(6):1425-33.

PMID: 25986597 PMC: 4666250. DOI: 10.1208/s12249-015-0335-8.

A review of common tanning methods.

Garone M, Howard J, Fabrikant J J Clin Aesthet Dermatol. 2015; 8(2):43-7.

PMID: 25741402 PMC: 4345932.