Rasagiline Alone and in Combination with Riluzole Prolongs Survival in an ALS Mouse Model

Overview

Journal J Neurol

Specialty Neurology

Date 2004 Sep 17

PMID 15372249

Citations 42

Authors

Stefan Waibel

Alexander Reuter

Susanne Malessa

Eran Blaugrund

Albert C Ludolph

Affiliations

Soon will be listed here.

Abstract

Rasagiline is an antiapoptotic compound with neuroprotective potential. We examined its neuroprotective effect alone and in combination with the putative glutamate release blocker riluzole in the G93A model of familial amyotrophic lateral sclerosis (fALS). Endpoints of experimental treatment were survival and motor activity. The drug had a significant dose-dependent therapeutic effect on both preclinical and clinical motor function and survival of the animals. We also found that the combination of rasagiline with riluzole is safe and increases survival by about 20 % in a dose-dependent manner. Therefore, we conclude that the combination of rasagiline and riluzole is a promising clinical combination for the improvement of current neuroprotective treatment strategies of ALS.

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