Phylogenetic Analysis of the Full-length SARS-CoV Sequences: Evidence for Phylogenetic Discordance in Three Genomic Regions

Overview

Journal J Med Virol

Specialty Microbiology

Date 2004 Sep 16

PMID 15368527

Citations 13

Authors

G Magiorkinis

E Magiorkinis

D Paraskevis

A M Vandamme

M Van Ranst

V Moulton

A Hatzakis

Affiliations

Soon will be listed here.

Abstract

The origin of the severe acute respiratory syndrome-coronavirus (SARS-CoV) remains unclear. Evidence based on Bayesian scanning plots and phylogenetic analysis using maximum likelihood (ML) and Bayesian methods indicates that SARS-CoV, for the largest part of the genome ( approximately 80%), is more closely related to Group II coronaviruses sequences, whereas in three regions in the ORF1ab gene it shows no apparent similarity to any of the previously characterized groups of coronaviruses. There is discordant phylogenetic clustering of SARS-CoV and coronaviruses sequences, throughout the genome, compatible with either ancient recombination events or altered evolutionary rates in different lineages, or a combination of both.

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