Developmental Changes in the Renal Capacity for Sulfate Reabsorption in the Guinea Pig

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 1992 Jan 1

PMID 1536743

Citations 4

Authors

R E Neiberger

Affiliations

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Abstract

During growth, immature guinea pigs maintain a positive inorganic sulfate balance. In the present study, renal clearance techniques were used to determine the maximum renal capacity for sulfate reabsorption [TmRsi/glomerular filtration rate (GFR)] in three groups of guinea pigs at different stages of development (10-34 days, 35-80 days and greater than 120 days of age). These ages are comparable to infant, adolescent, and adult guinea pigs. The guinea pigs were weaned at 10 days and then maintained on normal guinea pig chow (0.13% sulfate). The TmRsi/GFR was determined by infusions of increasing concentrations of sulfate (0-16.8 mumol/min). TmRsi/GFR was significantly greater in young (infant and adolescent) than in older (adult) guinea pigs (2.20 +/- 0.26 mumol/ml and 1.80 +/- 0.27 mumol/ml vs 0.942 +/- 0.08 mumol/ml, P less than 0.05). These results demonstrate that the tubular capacity for inorganic sulfate reabsorption per milliliter of glomerular filtrate is enhanced in immature guinea pigs and decreases with age.

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References

Lucke H, Stange G, Murer H . Sulphate-ion/sodium-ion co-transport by brush-border membrane vesicles isolated from rat kidney cortex. Biochem J. 1979; 182(1):223-9. PMC: 1161252. DOI: 10.1042/bj1820223. View

Cole D, McPhee M, Zlotkin S . Relationship between the sulfur content of total parenteral nutrition and sulfoester excretion in low-birthweight infants. Am J Clin Nutr. 1988; 47(1):128-33. DOI: 10.1093/ajcn/47.1.128. View

Johnson V, Spitzer A . Renal reabsorption of phosphate during development: whole-kidney events. Am J Physiol. 1986; 251(2 Pt 2):F251-6. DOI: 10.1152/ajprenal.1986.251.2.F251. View

Caverzasio J, Bonjour J, Fleisch H . Tubular handling of Pi in young growing and adult rats. Am J Physiol. 1982; 242(6):F705-10. DOI: 10.1152/ajprenal.1982.242.6.F705. View

Ito K, Kimata K, Sobue M, Suzuki S . Altered proteoglycan synthesis by epiphyseal cartilages in culture at low SO4(2-) concentration. J Biol Chem. 1982; 257(2):917-23. View

Larsson L, Horster M . Ultrastructure and net fluid transport in isolated perfused developing proximal tubules. J Ultrastruct Res. 1976; 54(2):276-85. DOI: 10.1016/s0022-5320(76)80156-6. View

Tyree B, Hassell J, Hascall V . Altered synthesis of heparan sulfate proteoglycans at low sulfate concentration. Arch Biochem Biophys. 1986; 250(1):202-10. DOI: 10.1016/0003-9861(86)90718-6. View

Humphries D, Silbert C, Silbert J . Glycosaminoglycan production by bovine aortic endothelial cells cultured in sulfate-depleted medium. J Biol Chem. 1986; 261(20):9122-7. View

Neiberger R, Barac-Nieto M, Spitzer A . Renal reabsorption of phosphate during development: transport kinetics in BBMV. Am J Physiol. 1989; 257(2 Pt 2):F268-74. DOI: 10.1152/ajprenal.1989.257.2.F268. View

10.

Cole D, Shafai J, Scriver C . Inorganic sulfate in cerebrospinal fluid from infants and children. Clin Chim Acta. 1982; 120(1):153-9. DOI: 10.1016/0009-8981(82)90086-9. View

11.

FUHR J, Kaczmarczyk J, KRUTTGEN C . [A simple colorimetric method of inulin determination in renal clearance studies on metabolically normal subjects and diabetics]. Klin Wochenschr. 1955; 33(29-30):729-30. DOI: 10.1007/BF01473295. View

12.

Ma R, Chan J . Endogenous sulphuric acid production: a method of measurement by extrapolation. Clin Biochem. 1973; 6(2):82-7. DOI: 10.1016/s0009-9120(73)80016-5. View

13.

Spitzer A, Brandis M . Functional and morphologic maturation of the superficial nephrons. Relationship to total kidney function. J Clin Invest. 1974; 53(1):279-87. PMC: 301463. DOI: 10.1172/JCI107548. View

14.

Sobue M, Takeuchi J, Ito K, Kimata K, Suzuki S . Effect of environmental sulfate concentration on the synthesis of low and high sulfated chondroitin sulfates by chick embryo cartilage. J Biol Chem. 1978; 253(17):6190-6. View

15.

Schneider E, Durham J, SACKTOR B . Sodium-dependent transport of inorganic sulfate by rabbit renal brush-border membrane vesicles. Effects of other ions. J Biol Chem. 1984; 259(23):14591-9. View

16.

Finnstrom O, Lundqvist P, Martensson J, SORBO B . The excretion of sulfur compounds in the urine of newborn infants. Metabolism. 1983; 32(7):732-5. DOI: 10.1016/0026-0495(83)90133-6. View

17.

Horster M, VALTIN H . ostnatal development of renal function: micropuncture and clearance studies in the dog. J Clin Invest. 1971; 50(4):779-95. PMC: 291992. DOI: 10.1172/JCI106549. View

18.

Kildeberg P, Engel K, WINTERS R . Balance of net acid in growing infants. Endogenous and transintestinal aspects. Acta Paediatr Scand. 1969; 58(4):321-9. DOI: 10.1111/j.1651-2227.1969.tb04728.x. View

19.

FETTERMAN G, SHUPLOCK N, PHILIPP F, GREGG H . THE GROWTH AND MATURATION OF HUMAN GLOMERULI AND PROXIMAL CONVOLUTIONS FROM TERM TO ADULTHOOD: STUDIES BY MICRODISSECTION. Pediatrics. 1965; 35:601-19. View

20.

Cole D, Scriver C . Age-dependent serum sulfate levels in children and adolescents. Clin Chim Acta. 1980; 107(1-2):135-9. DOI: 10.1016/0009-8981(80)90423-4. View