Tumour-stroma Interactions in Carcinogenesis: Basic Aspects and Perspectives

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2004 Sep 15

PMID 15362494

Citations 18

Authors

H Kiaris

I Chatzistamou

Ch Kalofoutis

H Koutselini

Ch Piperi

A Kalofoutis

Affiliations

Soon will be listed here.

Abstract

In contrast to the conventional notion regarding tumour development as a cell autonomous process in which the major participants were the cancer cells, increasing evidence attributes important role in the stromal components, namely fibroblasts, and view the tumour as a heterogenous mixture of different cell types. These different types of cells, being cancer cells, fibroblasts, endothelial cells, and others, interact reciprocally and play an almost equally important role in the manifestation of certain aspects of the malignant phenotype. The elucidation of the mechanistic base of such interactions, besides the contribution to understand fundamental aspects of tumour cell biology, promises important applications in diagnosis, prognosis and therapy of the disease.

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