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A Novel Metalloproteinase Gene Specifically Expressed in Stromal Cells of Breast Carcinomas

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Journal Nature
Specialty Science
Date 1990 Dec 20
PMID 1701851
Citations 256
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Abstract

A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.

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