Antigen-independent Acquisition of MHC Class II Molecules by Human T Lymphocytes

Overview

Journal Int Immunol

Specialty Allergy & Immunology

Date 2004 Sep 8

PMID 15351785

Citations 7

Authors

Anita H Undale

Peter J van den Elsen

Esteban Celis

Affiliations

Soon will be listed here.

Abstract

We report here that human T lymphocytes have the capacity of acquiring large amounts of MHC class II molecules from various types of antigen-presenting cells (APC) in an antigen-independent manner. The transfer of MHC class II molecules from APC to T cell required direct cell-to-cell contact and appeared to involve the interaction of numerous adhesion molecules between these cells. Depletion of cholesterol from the plasma membrane reduced the amount of MHC class II transferred onto the T cells. Most significantly, the newly acquired MHC class II molecules were capable of efficiently presenting antigen to T helper cells. These results suggest that T cells are able to interact with other T cells to regulate immune responses by presenting MHC peptide complexes that have been snatched away from nearby APC.

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References

Reith W, MACH B . The bare lymphocyte syndrome and the regulation of MHC expression. Annu Rev Immunol. 2001; 19:331-73. DOI: 10.1146/annurev.immunol.19.1.331. View

Kropshofer H, Spindeldreher S, Rohn T, Platania N, Grygar C, Daniel N . Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes. Nat Immunol. 2001; 3(1):61-8. DOI: 10.1038/ni750. View

Holling T, van der Stoep N, Quinten E, van den Elsen P . Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III. J Immunol. 2002; 168(2):763-70. DOI: 10.4049/jimmunol.168.2.763. View

Patel D, Dudek R, Mannie M . Intercellular exchange of class II MHC complexes: ultrastructural localization and functional presentation of adsorbed I-A/peptide complexes. Cell Immunol. 2002; 214(1):21-34. DOI: 10.1006/cimm.2002.1887. View

Hudrisier D, Bongrand P . Intercellular transfer of antigen-presenting cell determinants onto T cells: molecular mechanisms and biological significance. FASEB J. 2002; 16(6):477-86. DOI: 10.1096/fj.01-0933rev. View

Omiya R, Buteau C, Kobayashi H, Paya C, Celis E . Inhibition of EBV-induced lymphoproliferation by CD4(+) T cells specific for an MHC class II promiscuous epitope. J Immunol. 2002; 169(4):2172-9. DOI: 10.4049/jimmunol.169.4.2172. View

Tatari-Calderone Z, Tolouei Semnani R, Nutman T, Schlom J, Sabzevari H . Acquisition of CD80 by human T cells at early stages of activation: functional involvement of CD80 acquisition in T cell to T cell interaction. J Immunol. 2002; 169(11):6162-9. DOI: 10.4049/jimmunol.169.11.6162. View

Hiltbold E, Poloso N, Roche P . MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse. J Immunol. 2003; 170(3):1329-38. DOI: 10.4049/jimmunol.170.3.1329. View

Tsang J, Chai J, Lechler R . Antigen presentation by mouse CD4+ T cells involving acquired MHC class II:peptide complexes: another mechanism to limit clonal expansion?. Blood. 2002; 101(7):2704-10. DOI: 10.1182/blood-2002-04-1230. View

10.

Becart S, Setterblad N, Ostrand-Rosenberg S, Ono S, Charron D, Mooney N . Intracytoplasmic domains of MHC class II molecules are essential for lipid-raft-dependent signaling. J Cell Sci. 2003; 116(Pt 12):2565-75. DOI: 10.1242/jcs.00449. View

11.

Joly E, Hudrisier D . What is trogocytosis and what is its purpose?. Nat Immunol. 2003; 4(9):815. DOI: 10.1038/ni0903-815. View

12.

Holling T, Schooten E, Langerak A, van den Elsen P . Regulation of MHC class II expression in human T-cell malignancies. Blood. 2003; 103(4):1438-44. DOI: 10.1182/blood-2003-05-1491. View

13.

Fu S, Chiorazzi N, Wang C, Montrazeri G, KUNKEL H, Ko H . Ia-bearing T lymphocytes in man. Their identification and role in the generation of allogeneic helper activity. J Exp Med. 1978; 148(5):1423-8. PMC: 2185058. DOI: 10.1084/jem.148.5.1423. View

14.

Ko H, Fu S, Winchester R, Yu D, KUNKEL H . Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells. J Exp Med. 1979; 150(2):246-55. PMC: 2185627. DOI: 10.1084/jem.150.2.246. View

15.

Weekes M, Wills M, Mynard K, Hicks R, Sissons J, Carmichael A . Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57+ CD28- CD8+ T-cell population. Immunology. 1999; 98(3):443-9. PMC: 2326947. DOI: 10.1046/j.1365-2567.1999.00901.x. View

16.

Yu D, McCune J, Fu S, Winchester R, KUNKEL H . Two types of Ia-positive T cells. Synthesis and exchange of Ia antigens. J Exp Med. 1980; 152(2 Pt 2):89s-98s. View

17.

Lorber M, Loken M, Stall A, Fitch F . I-A antigens on cloned alloreactive murine T lymphocytes are acquired passively. J Immunol. 1982; 128(6):2798-803. View

18.

Swartz T, Evavold B, Suzuki H, Yokoyama A, Quintans J . Antigenicity of passively acquired major histocompatibility antigens on T cells. Transplantation. 1988; 46(1):137-43. DOI: 10.1097/00007890-198807000-00025. View

19.

Riddell S, Greenberg P . The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells. J Immunol Methods. 1990; 128(2):189-201. DOI: 10.1016/0022-1759(90)90210-m. View

20.

Oshima S, Eckels D . Selective signal transduction through the CD3 or CD2 complex is required for class II MHC expression by human T cells. J Immunol. 1990; 145(12):4018-25. View