ADAM 33 and Its Association with Airway Remodeling and Hyperresponsiveness in Asthma

Overview

Journal Clin Rev Allergy Immunol

Specialty Allergy & Immunology

Date 2004 Sep 7

PMID 15347848

Citations 11

Authors

Stephen T Holgate

Donna E Davies

Steuart Rorke

Julie Cakebread

Gillian Murphy

Robert M Powell

John W Holloway

Affiliations

Soon will be listed here.

Abstract

Asthma is known to be a Th2 inflammatory syndrome that leads to intermittent airway obstruction. However, the mechanisms involved in development of the clinical features remain enigmatic, although genetic elements clearly are involved. Recently, based on a large genome wide screen involving families in the United Kingdom and the United States with at least two siblings with asthma, a locus was identified that encoded for a family of proteases. This group of proteins is now known as the ADAM superfamily. In this review, we discuss the ADAM superfamily and, in particular, ADAM 33, a member of a family of genes which encode a subgroup of zinc dependent metalloproteinase (metzincin). The potential for therapeutic intervention with ADAM 33 is extremely attractive and further work will not only focus on the specific domains of ADAM 33, but also the mechanisms by which they lead to bronchial hyperreactivity.

Citing Articles

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