T2182C Mutation in 23S RRNA is Associated with Clarithromycin Resistance in Helicobacter Pylori Isolates Obtained in Bangladesh

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2004 Aug 26

PMID 15328128

Citations 26

Authors

Rasel Khan

Shamsun Nahar

Jinath Sultana

Mian Mashhud Ahmad

Motiur Rahman

Affiliations

Soon will be listed here.

Abstract

Twelve clarithromycin-resistant (MIC, > or = 1 microg/ml) Helicobacter pylori isolates were analyzed for point mutations in the 23S rRNA gene. Sequence analysis of all of the resistant isolates revealed a T-to-C transition mutation at position 2182. Transformation experiments confirmed that a single T-to-C transition mutation at position 2182 is associated with clarithromycin resistance.

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