Effects of Staphylococcus Aureus Cell Wall Products (teichoic Acid, Peptidoglycan) and Enterotoxin B on Immunoglobulin (IgE, IgA, IgG) Synthesis and CD23 Expression in Patients with Atopic Dermatitis

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1992 Jan 1

PMID 1531645

Citations 4

Authors

K Neuber

W Konig

Affiliations

Soon will be listed here.

Abstract

The influence of staphylococcal cell wall products (teichoic acid, peptidoglycan) and enterotoxin B on peripheral blood lymphocytes (PBL) from patients with atopic dermatitis (AD) was investigated. The parameters studied were spontaneous and interleukin-inducible immunoglobulin (IgA, IgE, IgG) synthesis and CD23 expression. PBL from non-atopic donors served as controls. Teichoic acid and peptidoglycan induced an enhanced synthesis of IgA and IgG in normal donors. However, IgA and IgG synthesis in PBL from patients with AD was significantly suppressed by teichoic acid and enterotoxin B. The incubation of PBL from normal donors with enterotoxin B and interleukin-4 (IL-4) or IL-5 led to a significant suppression of IgA and IgG synthesis. Co-stimulation of PBL with teichoic acid or peptidoglycan and IL-4 led to a pronounced increase in IgE synthesis and CD23 expression in patients with AD. Our data indicate that cell wall products and toxins of staphylococci modulate the cytokine-dependent humoral immunity in patients with AD and may be responsible for allergic skin reactions in AD.

Citing Articles

Dysbiotic Lesional Microbiome With Filaggrin Missense Variants Associate With Atopic Dermatitis in India.

Nath S, Kumari N, Bandyopadhyay D, Sinha N, Majumder P, Mitra R Front Cell Infect Microbiol. 2020; 10:570423.

PMID: 33282748 PMC: 7705349. DOI: 10.3389/fcimb.2020.570423.

Oxidative Stress in Atopic Dermatitis.

Ji H, Li X Oxid Med Cell Longev. 2016; 2016:2721469.

PMID: 27006746 PMC: 4781995. DOI: 10.1155/2016/2721469.

Immunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients.

Reginald K, Westritschnig K, Werfel T, Heratizadeh A, Novak N, Focke-Tejkl M Clin Exp Allergy. 2010; 41(3):357-69.

PMID: 21155910 PMC: 3057935. DOI: 10.1111/j.1365-2222.2010.03655.x.

Role of a carboxy-terminal site of toxic shock syndrome toxin 1 in eliciting immune responses of human peripheral blood mononuclear cells.

Drynda A, Konig B, Bonventre P, Konig W Infect Immun. 1995; 63(3):1095-101.

PMID: 7532624 PMC: 173115. DOI: 10.1128/iai.63.3.1095-1101.1995.

References

Pauwels R, Verschraegen G, VAN DER STRAETEN M . IgE antibodies to bacteria in patients with bronchial asthma. Allergy. 1980; 35(8):665-9. DOI: 10.1111/j.1398-9995.1980.tb02019.x. View

Klinman N, Taylor R . General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice. Clin Exp Immunol. 1969; 4(4):473-87. PMC: 1579022. View

Walsh G, Richards K, Douglas S, Blumenthal M . Immunoglobulin E anti-Staphylococcus aureus antibodies in atopic patients. J Clin Microbiol. 1981; 13(6):1046-8. PMC: 273947. DOI: 10.1128/jcm.13.6.1046-1048.1981. View

HERLITZ G . Bacterial infection and infantile eczema. Int Arch Allergy Appl Immunol. 1956; 8(3):160-4. DOI: 10.1159/000228278. View

Boyum A . Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol. 1976; Suppl 5:9-15. View

Jabara H, Fu S, Geha R, Vercelli D . CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J Exp Med. 1990; 172(6):1861-4. PMC: 2188752. DOI: 10.1084/jem.172.6.1861. View

Romagnani S . Regulation and deregulation of human IgE synthesis. Immunol Today. 1990; 11(9):316-21. DOI: 10.1016/s0167-5699(10)80004-0. View

Marrack P, Kappler J . The staphylococcal enterotoxins and their relatives. Science. 1990; 248(4956):705-11. DOI: 10.1126/science.2185544. View

Vercelli D, Jabara H, Arai K, Geha R . Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med. 1989; 169(4):1295-307. PMC: 2189234. DOI: 10.1084/jem.169.4.1295. View

10.

Bruijnzeel-Koomen C, Mudde G, Bruijnzeel P . The presence of IgE molecules on epidermal Langerhans cells in atopic dermatitis and their significance for its pathogenesis. Allerg Immunol (Paris). 1989; 21(6):219-23. View

11.

Lever R, Hadley K, Downey D, Mackie R . Staphylococcal colonization in atopic dermatitis and the effect of topical mupirocin therapy. Br J Dermatol. 1988; 119(2):189-98. DOI: 10.1111/j.1365-2133.1988.tb03201.x. View

12.

Hanifin J, Homburger H . Staphylococcal colonization, infection, and atopic dermatitis--association not etiology. J Allergy Clin Immunol. 1986; 78(4 Pt 1):563-6. DOI: 10.1016/0091-6749(86)90071-0. View

13.

Hauser C, Wuethrich B, Matter L, Wilhelm J, Schopfer K . Immune response to Staphylococcus aureus in atopic dermatitis. Dermatologica. 1985; 170(3):114-20. DOI: 10.1159/000249514. View

14.

Brasher G, Deiterman Jr L . Salivary IgA and infection in children with atopy. Ann Allergy. 1972; 30(5):241-4. View

15.

Bibel D, Aly R, Shinefield H, Maibach H, STRAUSS W . Importance of the keratinized epithelial cell in bacterial adherence. J Invest Dermatol. 1982; 79(4):250-3. DOI: 10.1111/1523-1747.ep12500072. View

16.

TEE R, Pepys J . Specific serum IgE antibodies to bacterial antigens in allergic lung disease. Clin Allergy. 1982; 12(5):439-50. DOI: 10.1111/j.1365-2222.1982.tb01642.x. View

17.

Gausset P, Delespesse G, Duchateau J, Collet H . In vitro response of human peripheral blood lymphocytes of protein A. DNA synthesis and generation of cells synthesizing the three major classes of Ig. Immunology. 1980; 41(4):891-7. PMC: 1458318. View

18.

Sainte-Laudy J, HENOCQ E . Reactivity of human basophils to anti-IgE and protein A in atopic dermatitis. Agents Actions. 1990; 30(1-2):250-3. DOI: 10.1007/BF01969052. View

19.

Neuber K, Stephan U, Franken J, Konig W . Staphylococcus aureus modifies the cytokine-induced immunoglobulin synthesis and CD23 expression in patients with atopic dermatitis. Immunology. 1991; 73(2):197-204. PMC: 1384465. View

20.

Springer T . Adhesion receptors of the immune system. Nature. 1990; 346(6283):425-34. DOI: 10.1038/346425a0. View