Validity of the Mindstreams Computerized Cognitive Battery for Mild Cognitive Impairment

Overview

Journal J Mol Neurosci

Specialties Molecular Biology
Neurology

Date 2004 Aug 18

PMID 15314247

Citations 25

Authors

Tzvi Dwolatzky

Victor Whitehead

Glen M Doniger

Ely S Simon

Avraham Schweiger

Dena Jaffe

Howard Chertkow

Affiliations

Soon will be listed here.

Abstract

The NeuroTrax Mindstreams computerized cognitive assessment system was designed for widespread clinical and research use in detecting mild cognitive impairment (MCI). However, the capability of Mindstreams tests to discriminate the elderly with MCI from those who are cognitively healthy has yet to be evaluated. Moreover, the comparability between these tests and traditional neuropsychological tests in detecting MCI has not been examined. A two-center study was designed to assess the discriminant validity of tests in the Mindstreams Mild Impairment Battery. Participants were 30 individuals diagnosed with MCI, 29 with mild Alzheimer's disease (AD), and 39 healthy elderly. Testing was with the Mindstreams battery and traditional neuropsychological tests. Receiver operating characteristic (ROC) analysis was used to examine the ability of Mindstreams and traditional measures to discriminate those with MCI from cognitively healthy elderly. Between-group comparisons were made (Mann-Whitney U test) between MCI and healthy elderly and between MCI and mild AD groups. Mindstreams outcome parameters across multiple cognitive domains significantly discriminated between MCI and healthy elders with considerable effect sizes (p < 0.05). Measures of memory, executive function, visual spatial skills, and verbal fluency discriminated best, and discriminability was at least comparable to that of traditional neuropsychological tests in these domains. Mindstreams tests are effective in detecting MCI, providing a comprehensive profile of cognitive function. Further, the enhanced precision and ease of use of these computerized tests make the NeuroTrax system a valuable clinical tool in the identification of elders at high risk for dementia.

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References

Ritchie K, Artero S, Touchon J . Classification criteria for mild cognitive impairment: a population-based validation study. Neurology. 2001; 56(1):37-42. DOI: 10.1212/wnl.56.1.37. View

Burns A, Zaudig M . Mild cognitive impairment in older people. Lancet. 2002; 360(9349):1963-5. DOI: 10.1016/S0140-6736(02)11920-9. View

Bozoki A, Giordani B, Heidebrink J, Berent S, Foster N . Mild cognitive impairments predict dementia in nondemented elderly patients with memory loss. Arch Neurol. 2001; 58(3):411-6. DOI: 10.1001/archneur.58.3.411. View

Kawas C, Corrada M, Brookmeyer R, Morrison A, Resnick S, Zonderman A . Visual memory predicts Alzheimer's disease more than a decade before diagnosis. Neurology. 2003; 60(7):1089-93. DOI: 10.1212/01.wnl.0000055813.36504.bf. View

Mohs R, ROSEN W, Davis K . The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy. Psychopharmacol Bull. 1983; 19(3):448-50. View

Elwood R . MicroCog: assessment of cognitive functioning. Neuropsychol Rev. 2001; 11(2):89-100. DOI: 10.1023/a:1016671201211. View

Green R, Green J, Harrison J, Kutner M . Screening for cognitive impairment in older individuals. Validation study of a computer-based test. Arch Neurol. 1994; 51(8):779-86. DOI: 10.1001/archneur.1994.00540200055017. View

Massoud F, Chertkow H, Whitehead V, Overbury O, Bergman H . Word-reading thresholds in Alzheimer disease and mild memory loss: a pilot study. Alzheimer Dis Assoc Disord. 2002; 16(1):31-9. DOI: 10.1097/00002093-200201000-00005. View

Petersen R, Smith G, Waring S, Ivnik R, Tangalos E, Kokmen E . Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999; 56(3):303-8. DOI: 10.1001/archneur.56.3.303. View

10.

Petersen R, Stevens J, Ganguli M, Tangalos E, Cummings J, DeKosky S . Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001; 56(9):1133-42. DOI: 10.1212/wnl.56.9.1133. View

11.

Albert M, Moss M, Tanzi R, Jones K . Preclinical prediction of AD using neuropsychological tests. J Int Neuropsychol Soc. 2001; 7(5):631-9. DOI: 10.1017/s1355617701755105. View

12.

Darby D, Maruff P, Collie A, McStephen M . Mild cognitive impairment can be detected by multiple assessments in a single day. Neurology. 2002; 59(7):1042-6. DOI: 10.1212/wnl.59.7.1042. View

13.

Petersen R, Doody R, Kurz A, Mohs R, Morris J, Rabins P . Current concepts in mild cognitive impairment. Arch Neurol. 2001; 58(12):1985-92. DOI: 10.1001/archneur.58.12.1985. View

14.

Macleod C . Half a century of research on the Stroop effect: an integrative review. Psychol Bull. 1991; 109(2):163-203. DOI: 10.1037/0033-2909.109.2.163. View

15.

Flicker C, Ferris S, Reisberg B . Mild cognitive impairment in the elderly: predictors of dementia. Neurology. 1991; 41(7):1006-9. DOI: 10.1212/wnl.41.7.1006. View

16.

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

17.

Kabani N, Sled J, Shuper A, Chertkow H . Regional magnetization transfer ratio changes in mild cognitive impairment. Magn Reson Med. 2002; 47(1):143-8. DOI: 10.1002/mrm.10028. View

18.

Mapstone M, Steffenella T, Duffy C . A visuospatial variant of mild cognitive impairment: getting lost between aging and AD. Neurology. 2003; 60(5):802-8. DOI: 10.1212/01.wnl.0000049471.76799.de. View

19.

Cauraugh J . Speed-accuracy tradeoff during response preparation. Res Q Exerc Sport. 1990; 61(4):331-7. DOI: 10.1080/02701367.1990.10607496. View

20.

Hanninen T, Hallikainen M, Koivisto K, Helkala E, Reinikainen K, Soininen H . A follow-up study of age-associated memory impairment: neuropsychological predictors of dementia. J Am Geriatr Soc. 1995; 43(9):1007-15. DOI: 10.1111/j.1532-5415.1995.tb05565.x. View