Stem Cells: Cross-talk and Developmental Programs

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2004 Aug 6

PMID 15293810

Citations 16

Authors

Jaime Imitola

Kook In Park

Yang D Teng

Sahar Nisim

Mahesh Lachyankar

Jitka Ourednik

Franz-Josef Mueller

Rene Yiou

Anthony Atala

Richard L Sidman

Mark Tuszynski

Samia J Khoury

Evan Y Snyder

Affiliations

Soon will be listed here.

Abstract

The thesis advanced in this essay is that stem cells-particularly those in the nervous system-are components in a series of inborn 'programs' that not only ensure normal development, but persist throughout life so as to maintain homeostasis in the face of perturbations-both small and great. These programs encode what has come to be called 'plasticity'. The stem cell is one of the repositories of this plasticity. This review examines the evidence that interaction between the neural stem cell (as a prototypical somatic stem cell) and the developing or injured brain is a dynamic, complex, ongoing reciprocal set of interactions where both entities are constantly in flux. We suggest that this interaction can be viewed almost from a 'systems biology' vantage point. We further advance the notion that clones of exogenous stem cells in transplantation paradigms may not only be viewed for their therapeutic potential, but also as biological tools for 'interrogating' the normal or abnormal central nervous system environment, indicating what salient cues (among the many present) are actually guiding the expression of these 'programs'; in other words, using the stem cell as a 'reporter cell'. Based on this type of analysis, we suggest some of the relevant molecular pathways responsible for this 'cross-talk' which, in turn, lead to proliferation, migration, cell genesis, trophic support, protection, guidance, detoxification, rescue, etc. This type of developmental insight, we propose, is required for the development of therapeutic strategies for neurodegenerative disease and other nervous system afflictions in humans. Understanding the relevant molecular pathways of stem cell repair phenotype should be a priority, in our view, for the entire stem cell field.

Citing Articles

Hydrogel-Based Therapies for Ischemic and Hemorrhagic Stroke: A Comprehensive Review.

Rotaru-Zavaleanu A, Dinescu V, Aldea M, Gresita A Gels. 2024; 10(7).

PMID: 39057499 PMC: 11276304. DOI: 10.3390/gels10070476.

Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum.

Holley S, Reidling J, Cepeda C, Wu J, Lim R, Lau A Mol Ther. 2023; 31(12):3545-3563.

PMID: 37807512 PMC: 10727970. DOI: 10.1016/j.ymthe.2023.10.003.

Modern Concepts in Regenerative Therapy for Ischemic Stroke: From Stem Cells for Promoting Angiogenesis to 3D-Bioprinted Scaffolds Customized via Carotid Shear Stress Analysis.

Benedek A, Cernica D, Mester A, Opincariu D, Hodas R, Rodean I Int J Mol Sci. 2019; 20(10).

PMID: 31130624 PMC: 6566983. DOI: 10.3390/ijms20102574.

HIV Non-Nucleoside Reverse Transcriptase Inhibitor Efavirenz Reduces Neural Stem Cell Proliferation in Vitro and in Vivo.

Jin J, Grimmig B, Izzo J, Brown L, Hudson C, Smith A Cell Transplant. 2017; 25(11):1967-1977.

PMID: 28836850 PMC: 5683847. DOI: 10.3727/096368916X691457.

Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro.

Xu P, Wang Y, Qin Z, Qiu L, Zhang M, Huang Y J Neuroimmune Pharmacol. 2017; 12(4):682-692.

PMID: 28735382 PMC: 5693968. DOI: 10.1007/s11481-017-9755-4.

References

Ourednik V, Ourednik J, Park K, Snyder E . Neural stem cells -- a versatile tool for cell replacement and gene therapy in the central nervous system. Clin Genet. 2000; 56(4):267-78. DOI: 10.1034/j.1399-0004.1999.560403.x. View

Park K, Liu S, Flax J, Nissim S, Stieg P, Snyder E . Transplantation of neural progenitor and stem cells: developmental insights may suggest new therapies for spinal cord and other CNS dysfunction. J Neurotrauma. 1999; 16(8):675-87. DOI: 10.1089/neu.1999.16.675. View

Magavi S, Leavitt B, Macklis J . Induction of neurogenesis in the neocortex of adult mice. Nature. 2000; 405(6789):951-5. DOI: 10.1038/35016083. View

Ourednik V, Ourednik J, Flax J, Zawada W, HUTT C, Yang C . Segregation of human neural stem cells in the developing primate forebrain. Science. 2001; 293(5536):1820-4. DOI: 10.1126/science.1060580. View

Himes B, Liu Y, Solowska J, Snyder E, Fischer I, Tessler A . Transplants of cells genetically modified to express neurotrophin-3 rescue axotomized Clarke's nucleus neurons after spinal cord hemisection in adult rats. J Neurosci Res. 2001; 65(6):549-64. DOI: 10.1002/jnr.1185. View

Teng Y, Lavik E, Qu X, Park K, Ourednik J, Zurakowski D . Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A. 2002; 99(5):3024-9. PMC: 122466. DOI: 10.1073/pnas.052678899. View

Zlomanczuk P, Mrugala M, de la Iglesia H, Ourednik V, Quesenberry P, Snyder E . Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus. Exp Neurol. 2002; 174(2):162-8. DOI: 10.1006/exnr.2001.7857. View

Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O . Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat Med. 2002; 8(9):963-70. DOI: 10.1038/nm747. View

Ourednik J, Ourednik V, Lynch W, Schachner M, Snyder E . Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat Biotechnol. 2002; 20(11):1103-10. DOI: 10.1038/nbt750. View

10.

Park K, Teng Y, Snyder E . The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue. Nat Biotechnol. 2002; 20(11):1111-7. DOI: 10.1038/nbt751. View

11.

Lu P, Jones L, Snyder E, Tuszynski M . Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neurol. 2003; 181(2):115-29. DOI: 10.1016/s0014-4886(03)00037-2. View

12.

Ryder E, Snyder E, Cepko C . Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer. J Neurobiol. 1990; 21(2):356-75. DOI: 10.1002/neu.480210209. View

13.

Snyder E, Deitcher D, Walsh C, Hartwieg E, Cepko C . Multipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell. 1992; 68(1):33-51. DOI: 10.1016/0092-8674(92)90204-p. View

14.

Reynolds B, Weiss S . Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 1992; 255(5052):1707-10. DOI: 10.1126/science.1553558. View

15.

Snyder E, Taylor R, Wolfe J . Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature. 1995; 374(6520):367-70. DOI: 10.1038/374367a0. View

16.

Suhonen J, Peterson D, Ray J, Gage F . Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature. 1996; 383(6601):624-7. DOI: 10.1038/383624a0. View

17.

Rosario C, Yandava B, Kosaras B, Zurakowski D, Sidman R, Snyder E . Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action. Development. 1997; 124(21):4213-24. DOI: 10.1242/dev.124.21.4213. View

18.

Flax J, Aurora S, Yang C, Simonin C, Wills A, Billinghurst L . Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat Biotechnol. 1998; 16(11):1033-9. DOI: 10.1038/3473. View

19.

Yandava B, Billinghurst L, Snyder E . "Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci U S A. 1999; 96(12):7029-34. PMC: 22044. DOI: 10.1073/pnas.96.12.7029. View

20.

Liu Y, Himes B, Solowska J, Moul J, Chow S, Park K . Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus. Exp Neurol. 1999; 158(1):9-26. DOI: 10.1006/exnr.1999.7079. View