Innate Immunity in Aging: Impact on Macrophage Function

Overview

Journal Aging Cell

Specialties Cell Biology
Geriatrics

Date 2004 Jul 23

PMID 15268749

Citations 153

Authors

Julie Plowden

Mary Renshaw-Hoelscher

Carrie Engleman

Jacqueline Katz

Suryaprakash Sambhara

Affiliations

Soon will be listed here.

Abstract

Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

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