Penazaphilones J-L, Three New Hydrophilic Azaphilone Pigments from and Their Anti-Inflammatory Activity

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Apr 13

PMID 37049911

Authors

Xia Zhang

Yeye Hu

Tao Yang

Xueqing Qian

Weicheng Hu

Guoyou Li

Affiliations

Soon will be listed here.

Abstract

Penazaphilones J-L (-), three new hydrophilic azaphilone pigments, as well as six known compounds, were discovered from the filamentous fungus cib-411. Compounds - were structurally elucidated by the detailed interpretation of their 1D and 2D NMR spectroscopic data. Compound is an unprecedented hybrid of an azaphilone and a glycerophosphate choline. Compounds and each contain an intact amino acid moiety. The bioassay showed that compound exhibited significant anti-inflammatory activity. Concretely, compound significantly suppressed the NO production, the expression levels of COX-2, IL-6, IL-1β, and iNOS mRNA in LPS-stimulated RAW264.7 cells. Moreover, treatment of compound prevented the translocation of NF-κB through inhibiting the phosphorylation of PI3K, PDK1, Akt, and GSK-3β. Thus, the inhibition of compound against LPS-induced inflammation should rely on its inactivation on NF-κB.

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