Requirement of Matrix Metalloproteinase-9 for the Transformation of Human Mammary Epithelial Cells by Stat3-C

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2004 Jul 14

PMID 15249664

Citations 116

Authors

Tobias N Dechow

Laura Pedranzini

Andrea Leitch

Kenneth Leslie

William L Gerald

Irina Linkov

Jacqueline F Bromberg

Affiliations

Soon will be listed here.

Abstract

Persistently activated Stat3 is found in many different cancers, including approximately 60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis.

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